ArticleEuropean heart journal2025
Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction.
Abstract read
In one paragraph
Article in European heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Established and emerging roles of lysosomal dysfunction in cardiac aging.Nature cardiovascular research · 2026Review
- Hierarchical endpoints and win statistics for geromedicine trials.Nature aging · 2026Review
- Heart failure in the elderly: epidemiology, mechanisms, and management.European heart journal · 2026Review
- Inflammation, metabolism, and aging in heart failure with preserved ejection fraction: Mechanisms and treatment perspectives.Journal of translational internal medicine · 2026Article
- Sirtuins in Medicine: Multifaceted Roles in Physiological Processes and Cardiovascular Diseases.Biomolecules · 2026Review
- Identification and validation of STEAP3 as a ferroptosis-related biomarker in heart failure.Frontiers in cardiovascular medicine · 2026Article
- Different forms of cardiomyocyte death in post-myocardial infarction ventricular remodeling: mechanisms and therapeutic strategies.Frontiers in cardiovascular medicine · 2026Review
- Multicenter HFpEF study identifies sex disparity linked with two discrete cardiac proteomic signatures.bioRxiv : the preprint server for biology · 2025Article
- FOXO1-NMNAT3 axis dysregulation promotes doxorubicin cardiotoxicity: NADRedox report : communications in free radical research · 2025Article
- NADAutophagy · 2025Article
- NADCells · 2025Review
- Specific targeting of adipose tissue metabolism is superior to caloric restriction in treating obesity-related HFpEF.Cardiovascular diabetology · 2025Article
- Nicotinamide Adenine Dinucleotide Supplementation to Alleviate Heart Failure: A Mitochondrial Dysfunction Perspective.Nutrients · 2025Review
- Potential Role of SESN3 in Linking Heart Failure with Preserved Ejection Fraction and Chronic Obstructive Pulmonary Disease via Autophagy Dysregulation.International journal of molecular sciences · 2025Article
- Mitochondrial dysfunction as a therapeutic nexus in HFpEF: therapeutic target and pharmacological advances.Frontiers in pharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Mahmoud AbdellatifDepartment of Cardiology, Medical University of Graz, Auenbruggerplatz 15, Graz 8036, Austria.ORCID 0000-0002-5042-9054
Francisco Vasques-NóvoaDepartment of Internal Medicine, Centro Hospitalar Universitário de São João, 4200-319 Porto, Portugal.
Viktoria Trummer-HerbstDepartment of Cardiology, Medical University of Graz, Auenbruggerplatz 15, Graz 8036, Austria.
Sylvère DurandMetabolomics and Cell Biology Platforms, Institut Gustave Roussy, 114 Rue Edouard Vaillant, Villejuif 94805, France.
Franziska KoserInstitute of Physiology II, University of Münster, Münster 48149, Germany.ORCID 0009-0008-9585-0935
Moydul IslamDivision of Cardiology and Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-3828-9562
Jihoon NahDepartment of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.ORCID 0000-0003-2254-2233
Eun-Ah SungDepartment of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.ORCID 0000-0002-1843-0338
Ruli FengDepartment of Cardiology, Medical University of Graz, Auenbruggerplatz 15, Graz 8036, Austria.
Fanny AprahamianMetabolomics and Cell Biology Platforms, Institut Gustave Roussy, 114 Rue Edouard Vaillant, Villejuif 94805, France.
Andreas ProkeschBioTechMed-Graz, Mozartgasse 12/I, Graz 8010, Austria.
Pablo Zardoya-LaguardiaDivision of Molecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, 8010 Graz, Austria.
Junichi SadoshimaDepartment of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.ORCID 0000-0003-3724-4132
Abhinav DiwanDivision of Cardiology and Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-7554-4772
Wolfgang A LinkeInstitute of Physiology II, University of Münster, Münster 48149, Germany.ORCID 0000-0003-0801-3773
João Pedro FerreiraDepartment of Internal Medicine, Centro Hospitalar Universitário de São João, 4200-319 Porto, Portugal.
Guido KroemerMetabolomics and Cell Biology Platforms, Institut Gustave Roussy, 114 Rue Edouard Vaillant, Villejuif 94805, France.ORCID 0000-0002-9334-4405
Simon SedejDepartment of Cardiology, Medical University of Graz, Auenbruggerplatz 15, Graz 8036, Austria.ORCID 0000-0002-4419-6821
Funding
ROLE OF AUTOPHAGIC FLUX IN CARDIAC MYOCYTE VIABILITYR01HL107594 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan · 2011 to 2026
$5.9MAustrian Science FundBioTechMed-GrazBLRD VA I01 BX005981Cardiovascular R&D Centre - UnICEU Horizon Europe Research and Innovation ProgramEuropean Research Area Network on Cardiovascular DiseasesMedical University of GrazMINOTAUR consortiumNHLBI NIH HHS R01 HL107594NIHPartnership Fostering a European Research Area for HealthPortuguese Foundation for Science and TechnologyUnited States of AmericaVA
Abstract
PubMed holds no abstract for this paper.
Indexed as
AutophagyHFpEFMetabolic cardiomyopathyMitophagyNAD+ metabolismObesity
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.