Evidence map›Paper›PMID 39995179›Full record

ArticleJournal of the American Chemical Society2025

Enantiopurity by Directed Evolution of Crystal Stabilities and Nonequilibrium Crystallization.

Clément Pinetre, Sjoerd W van Dongen, Clément Brandel, Anne-Sophie Léonard, Maxime D Charpentier, Valérie Dupray, Kasper Oosterling, Bernard Kaptein, Michel Leeman, Richard M Kellogg and 2 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. How Crystal Size and Number Steer Asymmetric Crystallization.The journal of physical chemistry letters · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Clément PinetreUniv Rouen Normandie, Normandie Univ, SMS, UR 3233, Rouen F-76000, France.ORCID 0000-0002-6805-369X
Sjoerd W van DongenAMOLF, Science Park 104, Amsterdam 1098 XG, The Netherlands.
Clément BrandelUniv Rouen Normandie, Normandie Univ, SMS, UR 3233, Rouen F-76000, France.ORCID 0000-0002-7747-0823
Anne-Sophie LéonardAMOLF, Science Park 104, Amsterdam 1098 XG, The Netherlands.
Maxime D CharpentierEPSRC Future Continuous Manufacturing and Advanced Crystallisation Research Hub, c/o Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G1 1RD, U.K.
Valérie DuprayUniv Rouen Normandie, Normandie Univ, SMS, UR 3233, Rouen F-76000, France.ORCID 0000-0001-6188-0943
Kasper OosterlingSymeres, Kadijk 3, Groningen 9747 AT, The Netherlands.
Bernard KapteinInnoSyn, Urmonderbaan 22, Geleen 6167 RD, The Netherlands.
Michel LeemanSymeres, Kadijk 3, Groningen 9747 AT, The Netherlands.
Richard M KelloggKellogg Beheer B.V., Zernikepark 12, Unit 1.31, Groningen 9747 AN, The Netherlands.ORCID 0000-0002-8409-829X
Joop H Ter HorstEPSRC Future Continuous Manufacturing and Advanced Crystallisation Research Hub, c/o Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G1 1RD, U.K.
Willem L NoorduinAMOLF, Science Park 104, Amsterdam 1098 XG, The Netherlands.ORCID 0000-0003-0028-2354

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crystallization is a powerful method to isolate enantiopure molecules from racemates if enantiomers self-sort into separate enantiopure crystals. Unfortunately, this behavior is unpredictable and rare (5-10%), as both enantiomers predominantly crystallize together to form racemic crystals, hindering any such chiral sorting. These unfavorable statistics might be overcome using nonequilibrium conditions. Therefore, we systematically characterize energy differences (Δ

Identifiers

PMID39995179
PMCPMC11912332

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.