Evidence map›Paper›PMID 39995127›Full record

ArticleCurrent vascular pharmacology2026

Hepatic Fibrosis Predicts the Prognosis of Patients with Acute Ischemic Stroke Through the Mediation of Cardioembolism.

Mingyue Zhao, Jiexi Huang, Tian Zeng, Minyue Zhang, Jiaqi Huang, Yufan Gao, Haobo Xie, Shengqi Li, Yilin Chen, Jiahan Xu and 4 more

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Article in Current vascular pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

14 authors.

Mingyue ZhaoDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jiexi HuangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Tian ZengDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Minyue ZhangDepartment of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jiaqi HuangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yufan GaoDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Haobo XieDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Shengqi LiDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yilin ChenDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jiahan XuDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yanchu WangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Shenyi LinDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yiyun WengDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Guangyong ChenDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Funding

Wenzhou Municipal Sci-Tech Bureau Program Y20220476
6 · The paper itself

Abstract

backgroundHepatic fibrosis, a chronic pathological condition, is associated with adverse outcomes in stroke patients. Cardioembolism (CE) is a common etiology of stroke, yet the association between hepatic fibrosis and CE remains understudied.

aimsThis study aims to investigate the association between hepatic fibrosis and CE-induced stroke, as well as its impact on stroke patient prognosis.

methodsThis retrospective study included 344 acute ischemic stroke (AIS) patients who underwent thrombolytic therapy. Hepatic fibrosis was assessed using the Fibrosis-4 (FIB-4) index and the Aspartate Aminotransferase-Platelet Ratio Index (APRI). Mediation analysis examined the role of CE in the association between hepatic fibrosis and 3-month functional outcomes.

resultsAmong 344 patients, 319 were classified using the Trial of Org 10172 in Acute Stroke Treatment criteria. Severe fibrosis (FIB-4 ≥ 2.01) was observed in 131 patients (38.08%), and CE was identified in 79 patients. FIB-4 was an independent predictor of CE (OR: 2.038, 95%CI: 1.507- 2.757, p < 0.001) and poor 3-month functional outcome (OR: 1.477, 95%CI: 1.103-1.978, p = 0.009) after adjusting for confounders. The effect of FIB-4 on poor 3-month functional outcomes was partially mediated by CE, with a mediation proportion of 30.63%.

conclusionHepatic fibrosis is a significant predictor of short-term functional outcomes in AIS, particularly cardioembolic stroke. The association between hepatic fibrosis and stroke outcomes is partially mediated through CE. These findings highlight the importance of assessing hepatic fibrosis in stroke patients, particularly those with CE etiology.

Indexed as

Heart DiseasesIschemic StrokeLiver CirrhosisAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk AssessmentRisk FactorsThrombolytic TherapyTime FactorsTreatment Outcomeacute ischemic strokeaminotransferase-plateletCardioembolismCE etiologyhepatic fibrosisstroke

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PMID39995127

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