Evidence map›Paper›PMID 39995124›Full record

ArticleCurrent pharmaceutical biotechnology2026

Preparation of Polydeoxyribonucleotide Nanoliposomes and their Applicability to Cosmetic Formulations.

Yifan He, Li Xu, Xiaojing Pei, Yinmao Dong, Xiangliang Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Current pharmaceutical biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yifan HeSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou, 510641, P.R. China.
Li XuCollege of Chemistry and Materials Engineering and Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing, 100048, P.R. China.
Xiaojing PeiCollege of Chemistry and Materials Engineering and Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing, 100048, P.R. China.
Yinmao DongCollege of Chemistry and Materials Engineering and Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing, 100048, P.R. China.
Xiangliang YangSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou, 510641, P.R. China.

Funding

National Natural Science Foundation of China 22004005
6 · The paper itself

Abstract

introductionThe use of polydeoxyribonucleotide (PDRN) in promoting tissue repair and antiaging has been hindered by several challenges, including its large molecular weight, susceptibility to decomposition, low bioavailability, and poor stability and skin permeability. Liposome formulation technology has emerged as a promising method in cosmetics, enhancing the penetration and protection of active ingredients.

methodsIn this study, a PDRN-loaded nanoliposomal (PDRN-NL) formulation, which exhibited an average particle size of 125 ± 1 nm, a polydispersity index (PDI) of 0.12 ± 0.02, a Zeta potential of -52.6 ± 0.8 mV, and an encapsulation efficiency of 81.3%. The stability of the PDRN-NL and its formulations was assessed using the Turbiscan Lab stability analyzer, which predicted a shelf life of up to three years. Furthermore, the in vitro permeability of the PDRNNL was evaluated using the Franz diffusion cell method.

resultsResults indicated that the cumulative skin permeation of PDRN-NL over 24 hours was 1.22 times higher than that of free PDRN, with skin retention of PDRN-NL being 1.40 times greater. The in vitro release studies demonstrated that liposomal encapsulation not only enhanced permeability but also provided a sustained-release effect and improved stability of PDRN.

conclusionOverall, the properties of liposome-encapsulated PDRN were significantly enhanced, presenting a novel solution for the incorporation of PDRN in the development of skincare products.

Indexed as

CosmeticsNanoparticlesPolydeoxyribonucleotidesAnimalsDrug StabilityLiposomesParticle SizePermeabilitySkinSkin AbsorptionSwineCosmeticsLiposomesPolydeoxyribonucleotidescosmeticdeliveryformulation applicationliposome-encapsulatednanoliposomePolydeoxyribonucleotide

Identifiers

PMID39995124

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.