Evidence map›Paper›PMID 39994806›Full record

ArticleMolecular neurodegeneration2025

Michael L Alosco, Jhony Mejía Pérez, Julia E Culhane, Ranjani Shankar, Christopher J Nowinski, Samantha Bureau, Nidhi Mundada, Karen Smith, Alinda Amuiri, Breton Asken and 22 more

Abstract read
In one paragraph

Article in Molecular neurodegeneration, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Quantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Michael L AloscoDepartment of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University, Chobanian & Avedisian School of Medicine, Boston, MA, USA.ORCID 0000-0002-8113-8428
Jhony Mejía PérezDepartment of Neurology, Alzheimer's Disease Research Center, Memory & Aging Center, University of California San Francisco, San Francisco, CA, USA.
Julia E CulhaneDepartment of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University, Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Ranjani ShankarDepartment of Neurology, Alzheimer's Disease Research Center, Memory & Aging Center, University of California San Francisco, San Francisco, CA, USA.
Christopher J NowinskiConcussion Legacy Foundation, Boston, MA, USA.
Samantha BureauConcussion Legacy Foundation, Boston, MA, USA.
Nidhi MundadaDepartment of Neurology, Alzheimer's Disease Research Center, Memory & Aging Center, University of California San Francisco, San Francisco, CA, USA.
Karen SmithDepartment of Neurology, Alzheimer's Disease Research Center, Memory & Aging Center, University of California San Francisco, San Francisco, CA, USA.
Alinda AmuiriDepartment of Neurology, Alzheimer's Disease Research Center, Memory & Aging Center, University of California San Francisco, San Francisco, CA, USA.
Breton AskenDepartment of Clinical & Health Psychology, 1Florida Alzheimer's Disease Research Center, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.
Jenna R GrohDepartment of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University, Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Annalise MinerDepartment of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University, Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Erika PettwayDepartment of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University, Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Sydney MosahebDepartment of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University, Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Yorghos TripodisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Charles WindonDepartment of Neurology, Alzheimer's Disease Research Center, Memory & Aging Center, University of California San Francisco, San Francisco, CA, USA.
Gustavo MercierMolecular Imaging and Nuclear Medicine, Boston Medical Center, Boston, MA, USA.
Robert A SternDepartment of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University, Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Lea T GrinbergDepartment of Neurology, Alzheimer's Disease Research Center, Memory & Aging Center, University of California San Francisco, San Francisco, CA, USA.
David N Soleimani-MeigooniDepartment of Neurology, Alzheimer's Disease Research Center, Memory & Aging Center, University of California San Francisco, San Francisco, CA, USA.
Bradley T ChristianWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, USA.
Tobey J BetthauserWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, USA.
Thor D SteinDepartment of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University, Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Ann C McKeeDepartment of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University, Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Chester A MathisDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Eric E AbrahamsonDepartment of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Milos D IkonomovicDepartment of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Sterling C JohnsonWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, USA.
Jesse MezDepartment of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University, Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Renaud La JoieDepartment of Neurology, Alzheimer's Disease Research Center, Memory & Aging Center, University of California San Francisco, San Francisco, CA, USA.
Daniel SchonhautDepartment of Neurology, Alzheimer's Disease Research Center, Memory & Aging Center, University of California San Francisco, San Francisco, CA, USA.
Gil D RabinoviciDepartment of Neurology, Alzheimer's Disease Research Center, Memory & Aging Center, University of California San Francisco, San Francisco, CA, USA. Gil.Rabinovici@ucsf.edu.

Funding

Research Education ComponentP30AG066468 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Julia K Kofler · 2020 to 2026
$29.4M
RL5: Research Education CoreP30AG072978 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Ann C. McKee · 2021 to 2026
$25.6M
Development of Emergent PET Tracers in Frontotemporal Lobar DegenerationK23AG076960 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David Nima Soleimani-Meigooni · 2022 to 2026
$951k
In Vivo Detection of Chronic Traumatic Encephalopathy with 18F-MK-6240 Tau PETR21NS120629 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALOSCO, MICHAEL, RABINOVICI, GIL DAN · 2021 to 2022
$461k
NIA NIH HHS K23 AG076960NIA NIH HHS P30 AG066468NIA NIH HHS P30AG066468NIA NIH HHS P30 AG072978NIA NIH HHS P30AG072978NINDS NIH HHS R21 NS120629NINDS NIH HHS R21NS120629
6 · The paper itself

Abstract

backgroundMolecular biomarkers of chronic traumatic encephalopathy (CTE) are lacking. We evaluated

methodsAutoradiography and in-vitro binding studies were done using

resultsAll six CTE stage III cases had Braak NFT stage III but no neuritic plaques. Two had Thal Phase 1 for Aβ; one showed a laminar pattern of

conclusionWe present evidence of

Indexed as

BrainChronic Traumatic EncephalopathyPositron-Emission Tomographytau ProteinsAgedAlzheimer DiseaseAutoradiographyFluorine RadioisotopesHumansIsoquinolinesMaleMiddle AgedFluorine RadioisotopesIsoquinolinesMK-6240tau ProteinsAlzheimer’s diseaseBiomarkersChronic traumatic encephalopathyMK-6240Repetitive head impactsTau PET

Identifiers

PMID39994806
PMCPMC11852567

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.