Evidence map›Paper›PMID 39994747›Full record

ArticleEuropean journal of medical research2025

Guillain-Barré syndrome (GBS) after severe/critical COVID-19 or COVID-19 vaccination.

Samira Bahrami, Behnaz Ansari, Leyla Norouzi-Barough, Bahram Bagherpour, Farzin Khorvash, Kiana Shirani, Saeed Abbasi, Roya Sherkat

Abstract readCase Reports
In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samira BahramiImmunodeficiency Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Behnaz AnsariDepartment of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.
Leyla Norouzi-BaroughImmunodeficiency Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Bahram BagherpourImmunodeficiency Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Farzin KhorvashInfectious Diseases Department, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Kiana ShiraniInfectious Diseases Department, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Saeed AbbasiAnesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Roya SherkatImmunodeficiency Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. royasherkat@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe global COVID-19 pandemic was initiated by the appearance of the novel coronavirus SARS-CoV-2 in 2019, presenting a spectrum of clinical manifestations from asymptomatic cases to severe pneumonia and multi-organ dysfunction, with some cases leading to death induced by hyperinflammatory responses. Neurological manifestations have been reported in more than one-third of COVID-19 patients, particularly in severe instances. While vaccines are pivotal in combating infectious diseases and enhancing public health, reports have linked Guillain-Barré syndrome (GBS) to COVID-19 vaccination and infection. This study seeks to analyze four cases of GBS associated with COVID-19.

methodsClinical and demographic data were collected from all patients diagnosed with GBS from a biobank, including patients with severe COVID-19 and those with autoimmune conditions resulting from COVID-19 infection or vaccination, who were referred to Alzahra University Hospital in Isfahan, Iran, between October 2020 and December. 2023.

resultsClinical and demographic data of affected patients are presented. This includes a unique family case involving a daughter who passed away due to GBS following AstraZeneca vaccination, her mother who succumbed to post-COVID-19 GBS, and her father who passed away from severe COVID-19 a year earlier.

conclusionsThese cases provide valuable insights into investigating potential genetic or epigenetic influences on GBS and hyperinflammation. Furthermore, the occurrence of GBS following exposure to COVID-19 and vaccination suggests shared pathways of autoimmunity induction by SARS-CoV-2 and vaccines.

Indexed as

COVID-19COVID-19 VaccinesGuillain-Barre SyndromeVaccinationAdultAgedChAdOx1 nCoV-19FemaleHumansIranMaleMiddle AgedSARS-CoV-2ChAdOx1 nCoV-19COVID-19 VaccinesAutoimmunityCOVID-19 infectionCOVID-19 vaccinationGBS

Identifiers

PMID39994747
PMCPMC11849160

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.