ArticleArthritis research & therapy2025
Impact of disease duration on systemic clinical profile in Sjogren's syndrome.
Article in Arthritis research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Leukopenia and systemic features in Sjögren's disease: a retrospective hospitalized cohort study.Clinical rheumatology · 2026Article
- Initial assessment of blood-brain barrier permeability alterations and associated clinical characteristics in patients with primary Sjögren's syndrome: Insights from DCE-MRI.Clinical rheumatology · 2026Article
- Exploring gender-related clinical and immunological profiles in Sjögren's disease in a Chinese cohort.Clinical rheumatology · 2025Article
- Frequency-dependent and temporal variability of low-frequency fluctuations in patients with primary Sjögren's syndrome.Lupus science & medicine · 2025Article
- A Review of the Current Clinical Aspects of Sjögren's Disease: Geographical Difference, Classification/Diagnostic Criteria, Recent Advancements in Diagnostic Methods, and Molecular Targeted Therapy.Journal of clinical medicine · 2025Review
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Authors and funding
4 authors.
Funding
Abstract
backgroundPrimary Sjogren's Syndrome (pSS) is a systemic autoimmune disorder characterized by lymphocyte infiltration of the exocrine glands. Disease duration plays a pivotal role in evaluating the development of SS. In this study, we aimed to clarify the clinical manifestations of pSS across various stages of its progression, thereby offering critical insights for early diagnosis and targeted management strategies for Sjogren's Syndrome.
methodsWe conducted a retrospective analysis involving 3,978 patients with primary Sjogren's Syndrome (mean [SD] age: 53.1[24] years) from Peking University People's Hospital between January 2015 and December 2022. We classified patients into five distinct groups based on the duration of the syndrome: T0 (≤ 1 year), T1 (> 1 year, ≤ 5 years), T2 (> 5 years, ≤ 10 years), T3 (> 10 years, ≤ 20 years), and T4 (> 20 years).
resultsWe observed a statistically significant increase in the percentage of pSS patients with white blood cell (WBC) decrease, specifically: T0 (9.23%), T1 (15.40%), T2 (22.62%), T3 (20.22%), T4 (26.45%). The decreases in hemoglobin (HGB) and platelet (PLT) were also robustly associated with extended disease duration (p < 0.0001). Simultaneously, systemic involvements aggravated with disease progression as incidence rates of skin, joint, lung, and nervous system were strikingly increased in each group. The findings also indicated that patients with long-term pSS exhibit a higher likelihood of developing comorbid conditions, such as diabetes and tumors. In summary, disease duration serves as a crucial determinant for the prognosis of patients with pSS.
conclusionsTherefore, early identification of symptoms and initiation of therapies are imperative for mitigating the risk of significant complications in pSS patients.
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