ReviewContraception and reproductive medicine2025
The association between age at menarche and infertility: a systematic review and meta-analysis of observational studies.
Review in Contraception and reproductive medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The distinctiveness of human aging I: Anthropological and developmental foundations.Zeitschrift fur Gerontologie und Geriatrie · 2026Review
- Application of Machine Learning Algorithms for Evaluating Predictors and Developing Diagnostic Models for Female Infertility Classification.Bioengineering (Basel, Switzerland) · 2026Article
- Age at menarche association with metabolic, reproductive, and sociodemographic factors: a population-based cross-sectional analysis using an outcome-wide framework in Geneva, Switzerland.European journal of public health · 2026Article
- A cross-sectional study of environmental quality and the timing of menarche and menopause in India using national survey and environmental monitoring datasets.Communications medicine · 2026Article
- Genetic association and potential mediators between age at menarche and cholelithiasis: a two-sample two-step bidirectional mendelian randomization study.BMC women's health · 2026Article
- Genetic heritability of age at menarche and its association with early menopause in the Korean population: a secondary data analysis.Journal of Korean biological nursing science · 2025Article
- Association between age at menarche and infertility in Tabari cohort population: a population-based case-control study.BMC research notes · 2025Article
- Are the Previously Reported Risk Factors for Endometriosis Actually Associated With Pain and Infertility Rather Than Endometriosis Itself?Reproductive medicine and biologyReview
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Authors and funding
5 authors.
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Abstract
objectiveBoth early and late age at menarche have been associated with various health issues and may influence the risk of infertility. This present study investigated the relationship between age at menarche and infertility risk.
methodsThis study follows PRISMA guidelines. Databases including PubMed, Scopus, Web of Science, Embase, and Cochrane were searched in December 2024. Odds ratios with 95% confidence intervals were estimated using a random-effects model. Heterogeneity was assessed with the I
resultsOut of 7,267 articles screened, 18 primary studies were included, yielding 21 pieces of evidence. The odds ratio (OR) for infertility in the late menarche group compared to the normal menarche group was 1.44 (95% CI: 0.98-2.10), while the OR for the early menarche group versus the normal menarche group was 0.98 (95% CI: 0.68-1.42). Additionally, the OR for infertility in the early menarche group compared to the late menarche group was 0.77 (95% CI: 0.55-1.06). For primary infertility, the OR for the late menarche group relative to the normal menarche group was 1.98 (95% CI: 1.02-3.85), whereas the OR for the early menarche group compared to the late menarche group was 0.59 (95% CI: 0.36-0.97).
conclusionAlthough the overall meta-analysis lacked statistical significance, subgroup analysis revealed a notable association between late menarche and primary infertility. Women with late menarche had higher odds of infertility, supporting a dose-responsive relationship. The observed 44% increase in infertility odds highlights late menarche as a potential risk factor, warranting further investigation into its implications for reproductive health.
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