Evidence map›Paper›PMID 39994714›Full record

ArticleBMC veterinary research2025

Age-based host response to Turkey arthritis reovirus in commercial Turkeys in the presence of maternally derived antibodies.

Saroj Khatiwada, John Ngunjiri, Patricia A Boley, Kush K Yadav, Amir Ghorbani, Michael Abundo, Carolyn M Lee, Jelmer W Poelstra, Chang-Won Lee, Saad Gharaibeh and 2 more

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Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Saroj KhatiwadaCenter for Food Animal Health, Department of Animal Sciences, College of Food, Agriculture and Environmental Sciences, The Ohio State University, Wooster, OH, USA.
John NgunjiriTARGAN Inc, Raleigh, NC, USA.
Patricia A BoleyCenter for Food Animal Health, Department of Animal Sciences, College of Food, Agriculture and Environmental Sciences, The Ohio State University, Wooster, OH, USA.
Kush K YadavCenter for Food Animal Health, Department of Animal Sciences, College of Food, Agriculture and Environmental Sciences, The Ohio State University, Wooster, OH, USA.
Amir GhorbaniCellular Biology Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Michael AbundoNortheast Ohio Medical University, Rootstown, OH, USA.
Carolyn M LeeCenter for Food Animal Health, Department of Animal Sciences, College of Food, Agriculture and Environmental Sciences, The Ohio State University, Wooster, OH, USA.
Jelmer W PoelstraMolecular and Cellular Imaging Center (MCIC), College of Food, Agriculture and Environmental Sciences, The Ohio State University, Wooster, OH, USA.
Chang-Won LeeSoutheast Poultry Research Laboratory, National Poultry Research Center, USDA Agricultural Research Service, United States Department of Agriculture, Athens, GA, USA.
Saad GharaibehDepartment of Pathology and Animal Health, Jordan University of Science and Technology, Irbid, Jordan.
Gireesh RajashekaraCenter for Food Animal Health, Department of Animal Sciences, College of Food, Agriculture and Environmental Sciences, The Ohio State University, Wooster, OH, USA.
Scott P KenneyCenter for Food Animal Health, Department of Animal Sciences, College of Food, Agriculture and Environmental Sciences, The Ohio State University, Wooster, OH, USA. kenney.157@osu.edu.

Funding

USDA NIFA AFRI 2021-67015-34465
6 · The paper itself

Abstract

backgroundTurkey arthritis reovirus (TARV) causes arthritic lameness in market-age turkeys. Since 2011, highly pathogenic TARV strains have caused significant economic losses in the turkey industry due to increased culling, reduced market weights, and decreased carcass quality, necessitating more effective control measures. Autogenous vaccine prevention strategies have been inefficacious partly due to a limited understanding of age-related susceptibility of turkeys to TARV. This study investigated age-related host and gut microbiota responses to TARV infection in commercial turkeys derived from vaccinated breeder hens. Poults with known maternally derived antibody titers were orally challenged with TARV O'Neil strain at 1-, 3-, and 7- weeks of age (WOA) and monitored for cloacal virus shedding, gastrocnemius tendon viral tropism, tendon inflammation, weight gain, and changes in gut microbiota.

resultsA transient TARV-induced weight gain suppression was evident in poults infected at 1- and 3- WOA during the first 3 weeks post-infection. Age-dependent variations in cloacal viral shedding, virus isolation from tendons, and tendon inflammation severity were also observed. There was significant dissimilarity in ileal and cecal bacterial communities between mock and infected groups, but the effect of age of infection was unclear.

conclusionsAge dependent host response was observed to TARV based on cloacal virus shedding, weight gain suppression and viral tendon tropism. Our study also indicates that maternally derived antibodies appeared insufficient to prevent virus translocation to the tendons and subsequent pathological changes. This study lays the groundwork for future investigations of better vaccines/vaccination strategies and alternative preventive measures. IMPORTANCE: Turkey arthritis reovirus (TARV) causes lameness due to arthritis and tenosynovitis, commonly in market-age turkeys, resulting in significant economic losses. As a control strategy, the turkey industry used autogenous vaccines, prepared from field TARV isolates in breeder hens, to protect the poults in the early stage of life through maternally derived antibodies (MDAs). This study establishes the level of protection provided by MDAs in young poults with age-based responses to TARV O'Neil reovirus strain. Additionally, this study reveals the dynamics of gut dysbiosis in infected poults at different timepoints, paving the way to ground-breaking investigations into gut microbiome modulation interventions that could potentially improve vaccine efficacy and reduce virus transmission and disease severity.

Indexed as

Immunity, Maternally-AcquiredOrthoreovirus, AvianPoultry DiseasesReoviridae InfectionsTurkeysAge FactorsAnimalsFemaleGastrointestinal MicrobiomeVirus Shedding

Identifiers

PMID39994714
PMCPMC11852562

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.