ArticleBMC public health2025
The prevalence of comorbidities and differences in noncommunicable diseases and nonrandom associations of comorbidities between HIV-infected and -uninfected individuals in Guangdong Province, China.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The process and mechanism of help-seeking behavior among people living with HIV: a qualitative analysis based on grounded theory.BMC public health · 2026Article
- Tools to Quantify and Characterize the Persistent Reservoir in People with HIV-1: Focus on Non-B Subtypes.Viruses · 2026Review
- Type 2 diabetes in people living with HIV: epidemiology, mechanisms, sex differences and early-life determinants.Frontiers in endocrinology · 2026Review
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3 authors.
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Abstract
backgroundGlobally, uncertainty persists regarding the prevalence of comorbidities in noncommunicable diseases (NCDs) among people living with HIV (PLWH) compared those without HIV. This uncertainty extends to the degree of nonrandom associations between comorbidities in both populations, particularly in resource-limited settings.
methodsThis cross-sectional study involved 343 HIV-infected individuals (cases) and 686 HIV-uninfected counterparts (controls), with a 1:2 individual matching ratio. Nonrandom associations between comorbidities were assessed using Somers' D statistic.
resultsComorbidity prevalence was significantly higher in cases (48.7%, 95% confidence interval [CI]: 43.4%-54.0%) than in controls (26.8%, 95% CI: 23.5%-30.1%). Cases exhibited more comorbidities than controls (6 and 4, respectively). Depression, cardiovascular diseases, chronic liver disease, chronic kidney disease, and chronic renal insufficiency were more prevalent among cases (25.7%, 7.9%, 11.1%, 3.5%, 2.0%, respectively) compared to controls. No significant differences were observed in the prevalence of diabetes mellitus, hypertension, chronic obstructive pulmonary disease, and musculoskeletal disorders between the two populations (cases: 7.9%, 12.5%, 0.3%, 6.4%, respectively; controls: 5.1%, 15.6%, 0.1%, 3.9%, respectively). Nonrandom associations between comorbidities were statistically significant in both groups, with Somers' D values ranging from 0.101 to 0.982 in cases and from 0.102 to 0.472 in controls.
conclusionsThe HIV-infected population demonstrates a higher prevalence of comorbidities compared to the HIV-uninfected population. Nonrandom associations between comorbidities exist in both populations, with stronger associations observed among PLWH.
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