Evidence map›Paper›PMID 39994631›Full record

ArticleMolecular cancer2025

Spatial transcriptomic analysis of tumor microenvironment in esophageal squamous cell carcinoma with HIV infection.

Yuanli Zuo, Yang Jin, Gang Li, Yue Ming, Ting Fan, Yitong Pan, Xiaojun Yao, Yong Peng

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PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yuanli Zuo *Center for Molecular Oncology, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Respiratory Health and Multimorbidity, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Yang Jin *Center for Molecular Oncology, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Respiratory Health and Multimorbidity, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Gang Li *Department of Thoracic Surgery, The Public Health Clinical Center of Chengdu, Chengdu, 610061, China.
Yue MingCenter for Molecular Oncology, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Respiratory Health and Multimorbidity, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Ting FanCenter for Molecular Oncology, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Respiratory Health and Multimorbidity, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Yitong PanCenter for Molecular Oncology, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Respiratory Health and Multimorbidity, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xiaojun YaoDepartment of Thoracic Surgery, The Public Health Clinical Center of Chengdu, Chengdu, 610061, China. flyingyao@163.com.
Yong PengCenter for Molecular Oncology, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Respiratory Health and Multimorbidity, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China. yongpeng@scu.edu.cn.

Funding

National Natural Science Foundation of China 32100524National Natural Science Foundation of China U24A20721the 1.3.5 Project for Disciplines of Excellence, West China Hospital of Sichuan University ZYGD23027
6 · The paper itself

Abstract

backgroundHuman Immunodeficiency Virus (HIV) is one of the most prevalent viruses, causing significant immune depletion in affected individuals. Current treatments can control HIV and prolong patients' lives, but new challenges have emerged. Increasing incidence of cancers occur in HIV patients. Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers observed in HIV patients. However, the spatial cellular characteristics of HIV-related ESCC have not been explored, and the differences between HIV-ESCC and typical ESCC remain unclear.

methodsWe performed spatial transcriptome sequencing on HIV-ESCC samples to depict the microenvironment and employed cell communication analysis and multiplex immunofluorescence to investigate the molecular mechanism in HIV-ESCC.

resultsWe found that HIV-ESCC exhibited a unique cellular composition, with fibroblasts and epithelial cells intermixed throughout the tumor tissue, lacking obvious spatial separation, while other cell types were sparse. Besides, HIV-ESCC exhibited an immune desert phenotype, characterized by a low degree of immune cell infiltration, with only a few SPP1

conclusionsOur findings depict the spatial microenvironment of HIV-ESCC and elucidate a molecular mechanism in the progression of HIV-ESCC. This will provide us insights into the molecular basis of HIV-ESCC and potential treatment strategies.

Indexed as

Esophageal NeoplasmsEsophageal Squamous Cell CarcinomaGene Expression ProfilingHIV InfectionsTranscriptomeTumor MicroenvironmentBiomarkers, TumorGene Expression Regulation, NeoplasticHumansSignal TransductionBiomarkers, TumorEsophageal squamous cell carcinomaHIVSpatial transcriptomeTumor microenvironment

Identifiers

PMID39994631
PMCPMC11853777

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