ArticleBMC ophthalmology2025
Elevated hyperreflective foci as a novel characteristic in idiopathic epiretinal membrane by optical coherence tomography angiography.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Hyperreflective Foci in the Ectopic Inner Foveal Layer of Advanced Idiopathic Epiretinal Membranes.Investigative ophthalmology & visual science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe objective of this study was to analyze hyperreflective foci at the vitreous-retinal interface in cases of idiopathic epiretinal membrane (iERM) using enface-OCT.
methodsThis study included 47 patients (52 eyes) diagnosed with iERM between January 2020 and July 2023. We observed changes in hyperreflective foci in the macular area at each stage of iERM using OCTA on a 6 mm slab of the VRI. Evaluations included the density and percentage of hyperreflective foci of the epiretinal membrane at each stage, as well as the relationship between hyperreflective foci density and other OCT parameters, such as macular thickness and changes in macular superficial vascular density.
resultsStatistically significant differences in hyperreflective foci density and percentage were observed across the four stages of patients (p < 0.05). Additionally, statistically significant differences in superficial vascular density were noted among the four stages (p < 0.05). Hyperreflective foci area percentage and density correlated significantly with hyperreflective foci, FAZ area, and FAZ perimeter (p < 0.005). However, no correlation was found between hyperreflective foci density and area percentage with superficial vascular density and superficial perfusion density (p > 0.05).
conclusionHyperreflective foci were identified in all stages of iERM, with their number and density increasing as the disease progressed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.