Evidence map›Paper›PMID 39994546›Full record

ReviewThe journal of headache and pain2025

Sex difference in TRPM3 channel functioning in nociceptive and vascular systems: an emerging target for migraine therapy in females?

Georgii Krivoshein, Eduardo Rivera-Mancilla, Antoinette MaassenVanDenBrink, Rashid Giniatullin, Arn M J M van den Maagdenberg

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of headache and pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. The therapeutic pipeline in migraine: What does the future hold?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Georgii KrivosheinDepartments of Human Genetics and Neurology, Leiden University Medical Center, PO Box 9600 2300 RC, Leiden, The Netherlands.
Eduardo Rivera-MancillaDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Antoinette MaassenVanDenBrinkDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Rashid GiniatullinA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Arn M J M van den MaagdenbergDepartments of Human Genetics and Neurology, Leiden University Medical Center, PO Box 9600 2300 RC, Leiden, The Netherlands. a.m.j.m.van_den_maagdenberg@lumc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transient Receptor Potential Melastatin 3 (TRPM3) channels are Ca

Indexed as

Migraine DisordersNociceptionSex CharacteristicsTRPM Cation ChannelsAnimalsCalcitonin Gene-Related PeptideFemaleHumansMaleCalcitonin Gene-Related PeptideTRPM3 protein, humanTRPM Cation ChannelsEstrogenMigraineNociceptionPregnenolone sulfateProgesteroneSex dimorphismTRPM3

Identifiers

PMID39994546
PMCPMC11853570

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.