Evidence map›Paper›PMID 39994495›Full record

ArticleDrug and alcohol review2025

Hospital admission costs of acute injection-related infections among people who inject drugs.

Freya J Langham, Stephanie J Curtis, Mei Jie Tang, Bismi Jomon, Joseph S Doyle, Olga Vujovic, Andrew J Stewardson, Hannah E Carter

Abstract read
In one paragraph

Article in Drug and alcohol review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Freya J LanghamDepartment of Infectious Diseases, The Alfred Hospital and School of Translational Medicine, Monash University, Melbourne, Australia.ORCID 0000-0001-8125-7526
Stephanie J CurtisDepartment of Infectious Diseases, The Alfred Hospital and School of Translational Medicine, Monash University, Melbourne, Australia.ORCID 0000-0002-6724-0020
Mei Jie TangDepartment of Infectious Diseases, The Alfred Hospital and School of Translational Medicine, Monash University, Melbourne, Australia.
Bismi JomonData and Analytics Services, The Alfred Hospital, Melbourne, Australia.
Joseph S DoyleDepartment of Infectious Diseases, The Alfred Hospital and School of Translational Medicine, Monash University, Melbourne, Australia.
Olga VujovicDepartment of Infectious Diseases, The Alfred Hospital and School of Translational Medicine, Monash University, Melbourne, Australia.
Andrew J StewardsonDepartment of Infectious Diseases, The Alfred Hospital and School of Translational Medicine, Monash University, Melbourne, Australia.ORCID 0000-0001-6805-1224
Hannah E CarterAustralian Centre for Health Services Innovation and Centre for Healthcare Transformation, School of Public Health & Social Work, Faculty of Health, Queensland University of Technology, Brisbane, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere are limited existing data regarding the financial costs associated with hospitalisation for injection-related infection (IRI) in Australia. We aimed to estimate the cost, from the healthcare funder perspective, of admissions to treat IRI.

methodsWe performed a retrospective audit of 226 admissions with an IRI at the Alfred Hospital (Melbourne, Australia), from January 2017 to April 2019. Eligibility criteria included admission for management of an IRI and current injecting drug use, defined as self-reported injecting drug use within the preceding 6 months, documented in the medical record. We estimated the cost of each hospital admission, using national hospital price weights that accounted for the Australian Refined Diagnosis Related Groups and length of stay.

resultsAmong admissions with IRI, the median (interquartile range; IQR) cost of admissions with uncomplicated skin and soft tissue infection and complicated infection were AU$8416 (IQR $4132-$8611) and AU$31,938 (IQR $14,301-$54,397), respectively. Admissions requiring intensive care or surgery were associated with higher costs. The most expensive infection based on hospital cost was spinal infections (median AU$58,366 [IQR 31,938-$69,001]), despite endocarditis having higher median length of stay (38 days [IQR 18-46] vs. 24 [15-32]). DISCUSSION AND

conclusionsWe demonstrate the costs associated with hospital admissions for IRI, including the substantial increased costs associated with complicated IRI. This highlights the opportunity for cost savings associated with harm minimisation interventions to avoid infections and their sequelae.

Indexed as

Hospital CostsHospitalizationInfectionsSubstance Abuse, IntravenousAdultAustraliaFemaleHumansLength of StayMaleMiddle AgedRetrospective Studiescosthospitalisationinjecting drug useinjection‐related infectionssubstance‐related disorders

Identifiers

PMID39994495
PMCPMC11886475

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.