ArticleNature chemistry2025
Light-activated hypervalent iodine agents enable diverse aliphatic C-H functionalization.
Article in Nature chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Second-Harmonic Hyper-Mie Optical Activity Enables Closed-Loop Chiral Photochemistry.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Accessing Molecular Complexity from Methane and Other Gaseous Alkanes via Photocatalytic Cascade Cyclization.Angewandte Chemie (International ed. in English) · 2026Article
- Multisite Proton-Coupled Electron Transfer Enables Iodanyl Radical Catalysis.Journal of the American Chemical Society · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The functionalization of aliphatic C-H bonds is a crucial step in the synthesis and transformation of complex molecules relevant to medicinal, agricultural and materials chemistry. As such, there is substantial interest in the development of general synthetic platforms that enable the efficient diversification of aliphatic C-H bonds. Here we report a hypervalent iodine reagent that releases a potent hydrogen atom abstractor for C-H activation under mild photochemical conditions. Using this reagent, we demonstrate selective (N-phenyltetrazole)thiolation of aliphatic C-H bonds for a broad scope of substrates. The synthetic utility of the thiolated products is showcased through various derivatizations. Simply by altering the radical trapping agent, our method can directly transform C-H bonds into diverse functionalities, including C-S, C-Cl, C-Br, C-I, C-O, C-N, C-C and C=C bonds.
Identifiers
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Registered trials
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