Evidence map›Paper›PMID 39994479›Full record

ArticleNature aging2025

What makes biological age epigenetic clocks tick.

Mahdi Moqri, Jesse R Poganik, Steve Horvath, Vadim N Gladyshev

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Embracing non-linearity in human ageing.Nature reviews. Genetics · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mahdi MoqriDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. mmoqri@bwh.harvard.edu.ORCID http://orcid.org/0000-0001-6675-0566
Jesse R PoganikDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3098-8550
Steve HorvathDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-4110-3589
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. vgladyshev@rics.bwh.harvard.edu.

Funding

The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI JAN VIJG · 2014 to 2026
$36.9M
Understanding Interorgan Communication Through Heterochronic Organ TransplantationU01AG086168 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Vadim N. Gladyshev, Stefan Gunther Tullius · 2024 to 2026
$2.0M
NIA NIH HHS P01 AG047200NIA NIH HHS U01 AG086168U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG047200
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39994479
PMCPMC12867034

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.