Evidence map›Paper›PMID 39994472›Full record

ArticleNature genetics2025

Secure and federated genome-wide association studies for biobank-scale datasets.

Hyunghoon Cho, David Froelicher, Jeffrey Chen, Manaswitha Edupalli, Apostolos Pyrgelis, Juan R Troncoso-Pastoriza, Jean-Pierre Hubaux, Bonnie Berger

Abstract read
In one paragraph

Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Biobanking: IoT, safety challenges and security prospects.BMC medical informatics and decision making · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Computationally efficient whole-genome quantile regression at biobank scale.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Privacy-Enhancing Technologies in Biomedical Data Science.Annual review of biomedical data science · 2024
    Review
  18. Article
  19. Article
  20. Secure Discovery of Genetic Relatives across Large-Scale and Distributed Genomic Datasets.Research in computational molecular biology : ... Annual International Conference, RECOMB ... : proceedings. RECOMB (Conference : 2005- )
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hyunghoon Cho *Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, USA. hoon.cho@yale.edu.ORCID http://orcid.org/0000-0002-2713-0150
David Froelicher *Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jeffrey ChenBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Manaswitha EdupalliBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Apostolos PyrgelisSchool of Computer and Communication Sciences, EPFL, Lausanne, Switzerland.
Juan R Troncoso-PastorizaTune Insight SA, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-8764-5570
Jean-Pierre HubauxSchool of Computer and Communication Sciences, EPFL, Lausanne, Switzerland. jean-pierre.hubaux@epfl.ch.ORCID http://orcid.org/0000-0003-1533-6132
Bonnie BergerBroad Institute of MIT and Harvard, Cambridge, MA, USA. bab@mit.edu.ORCID http://orcid.org/0000-0002-2724-7228

Funding

Genetic & Social Determinants of Health: Center for Admixture Science and TechnologyRM1HG011558 · NHGRI · YALE UNIVERSITY · PI FRAZER, KELLY A, GYMREK, MELISSA · 2021 to 2025
$11.2M
Privacy-preserving genomic medicine at scaleR01HG010959 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BERGER, BONNIE · 2020 to 2023
$2.6M
Computational Methods for Enhancing Privacy in Biomedical Data SharingDP5OD029574 · OD · YALE UNIVERSITY · PI CHO, HYUNGHOON · 2020 to 2024
$2.0M
NHGRI NIH HHS R01 HG010959NHGRI NIH HHS RM1 HG011558NIH HHS DP5 OD029574ODCDC CDC HHS DP5 OD029574
6 · The paper itself

Abstract

Sharing data across institutions for genome-wide association studies (GWAS) would enhance the discovery of genetic variation linked to health and disease

Indexed as

Biological Specimen BanksComputer SecurityGenome-Wide Association StudyAlgorithmsDatabases, GeneticHumansInformation Dissemination

Identifiers

PMID39994472
PMCPMC11985345

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.