Synthesis and application of diazenyl sulfonamide-based schiff bases as potential BRCA2 active inhibitors against MCF-7 breast cancer cell line.

Olia Rezaeianzadeh, Sakineh Asghari, Mahmood Tajbakhsh, Asieh Khalilpour, Sergey Shityakov

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Computational Investigation of Novel pUL56 Ligands Using Docking and Molecular Dynamics with Preliminary Cytotoxicity Evaluation: An Early-Stage Study.Molecules (Basel, Switzerland) · 2026
Article
Breaking Boundaries in Cancer Therapy: Harnessing Chromothripsisinduced Mutations for Targeted Bcl-2 Protein Destabilization.Current drug discovery technologies · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Olia RezaeianzadehDepartment of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, 47416- 95447, Iran.

Sakineh AsghariDepartment of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, 47416- 95447, Iran. s.asghari@umz.ac.ir.

Mahmood TajbakhshDepartment of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, 47416- 95447, Iran.

Asieh KhalilpourDepartment of Environmental Health Engineering, Babol University of Medicinal Sciences, Babol, Iran.

Sergey ShityakovInfochemistry Scientific Center, ITMO University, Lomonosova str. 9, 191002, Saint Petersburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, a library of novel sulfonamide-based Schiff bases 3a-j was synthesized in high yield (75 to 89%). The FTIR,

Indexed as

Antineoplastic AgentsBRCA2 ProteinBreast NeoplasmsSulfonamidesCell ProliferationFemaleHumansMCF-7 CellsMolecular Docking SimulationMolecular Dynamics SimulationSchiff BasesAntineoplastic AgentsBRCA2 ProteinBRCA2 protein, humanSchiff BasesSulfonamidesBRCA2CytotoxicityMCF-7 breast cancer cell lineSulfonamide-based schiff baseSulfonamides

Identifiers

PMID39994448

DOI10.1038/1811199a0

PMCPMC11850876

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.