Evidence map›Paper›PMID 39994445›Full record

ArticleBritish journal of cancer2025

Potentiation of immune checkpoint blockade with a pH-sensitizer as monitored in two pre-clinical tumor models with acidoCEST MRI.

Renee L Tran, Tianzhe Li, Jorge de la Cerda, F William Schuler, Alia S Khaled, Shivanand Pudakalakatti, Pratip K Bhattacharya, Sanhita Sinharay, Mark D Pagel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Renee L TranDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, USA.
Tianzhe LiDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, USA.
Jorge de la CerdaDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, USA.
F William SchulerDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, USA.
Alia S KhaledDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, USA.
Shivanand PudakalakattiDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, USA.
Pratip K BhattacharyaDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, USA.
Sanhita SinharayCentre for Biosystems Science & Engineering, Indian Institute of Science, Bangalore, India.
Mark D PagelDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, USA. mdpagel2@wisc.edu.ORCID http://orcid.org/0000-0002-8109-3995

Funding

Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) RP220270
6 · The paper itself

Abstract

backgroundTumor acidosis causes resistance to immune checkpoint blockade (ICB). We hypothesized that a "pH-sensitizer" can increase tumor extracellular pH (pHe) and improve tumor control following ICB. We also hypothesized that pHe measured with acidoCEST MRI can predict improved tumor control with ICB.

methodsWe tested the effects of pH-sensitizers on proton efflux rate (PER), cytotoxicity, T cell activation, tumor immunogenicity, tumor growth and survival using 4T1 and B16-F10 tumor cells. We measured in vivo tumor pHe of 4T1 and B16-F10 models with acidoCEST MRI.

resultsAmong the pH-sensitizers tested, someprazole caused the greatest reduction in PER without exhibiting cytotoxicity or reducing T cell activation. Esomeprazole improved 4T1 tumor control with ICB administered one day after the pH-sensitizer. Tumor pHe positively correlated with TCF-1 + CD4 effector and CD8 T cell intratumoral frequencies and predicted improved 4T1 tumor control with ICB. For comparison, esomeprazole had a mild effect on B16-F10 tumor pHe, and worsened tumor control with ICB and increased intratumoral myeloid and dendritic cell (DC) frequencies.

conclusionsA pH-sensitizer can improve tumor control with ICB, and acidoCEST MRI can be used to measure pHe and predict tumor control, but only in the 4T1 model and not the B16-F10 model.

Indexed as

Immune Checkpoint InhibitorsMagnetic Resonance ImagingAnimalsCell Line, TumorDisease Models, AnimalEsomeprazoleFemaleHumansHydrogen-Ion ConcentrationMiceMice, Inbred BALB CMice, Inbred C57BLEsomeprazoleImmune Checkpoint Inhibitors

Identifiers

PMID39994445
PMCPMC11997056

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