ArticleScientific reports2025
Cardiac parasympathetic denervation reduces hypoxic tachycardia, baroreflex sensitivity and heart rate variability in humans.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Cardioneuroablation Acutely Affects the Amplitude and Efficiency of Respiratory Heart Rate Variability.Journal of clinical medicine · 2026Article
- Heart-focused breathing technique and attitude breathing technique effects on heart rate variability in young healthy subjects.Physiological reports · 2025Article
- Molecular and Biochemical Mechanisms of Cardiomyopathy Development Following Prenatal Hypoxia-Focus on the NO System.Antioxidants (Basel, Switzerland) · 2025Review
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Authors and funding
5 authors.
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Abstract
The autonomic regulation of heart rate (HR) reactivity to acute hypoxia remains unclear. Parasympathetic cardioneuroablation (PCNA) may serve as a novel model for the analysis of physiological consequences of reduced vagal influence over sinus node in humans. We studied 11 adult patients scheduled for PCNA for the treatment of vasovagal syncope. HR reactivity to hypoxia was studied before and after PCNA with brief nitrogen gas administrations. Each test was followed by an atropine challenge to evaluate the contribution of parasympathetic tone to the resting HR. Additionally, we assessed changes in cardiac baroreflex sensitivity and HR variability following the procedure. PCNA led to partial parasympathetic denervation of sinus node at rest (67.0 ± 20.1%). This translated into a significant change in HR reactivity to hypoxia (0.58 ± 0.21 vs. 0.22 ± 0.13 beats min
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