Evidence map›Paper›PMID 39994427›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Precision Stealth Nanofibers via PET-RAFT Polymerisation: Synthesis, Crystallization-driven Self-assembly and Cellular Uptake Studies.

Steven T G Street, Ekaterina Shteinberg, Juan Diego Garcia Hernandez, Hayley C Parkin, Robert L Harniman, Stephanie Willerth, Ian Manners

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Steven T G StreetSchool of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, United Kingdom.ORCID https://orcid.org/0000-0002-7635-8733
Ekaterina ShteinbergDepartment of Mechanical Engineering, Division of Medical Sciences, University of Victoria, 3800 Finnerty Rd, Victoria, BC, V8W 2Y2, Canada.ORCID https://orcid.org/0000-0002-5670-1290
Juan Diego Garcia HernandezSchool of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, United Kingdom.ORCID https://orcid.org/0000-0001-6343-5659
Hayley C ParkinDepartment of Chemistry, University of Victoria, 3800 Finnerty Rd, Victoria, BC, V8W 3V6, Canada.ORCID https://orcid.org/0000-0002-3218-1411
Robert L HarnimanSchool of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, United Kingdom.ORCID https://orcid.org/0000-0002-3452-1213
Stephanie WillerthCentre for Advanced Materials and Related Technology (CAMTEC), University of Victoria, 3800 Finnerty Rd, Victoria, BC, V8P 5C2, Canada.ORCID https://orcid.org/0000-0002-1665-7723
Ian MannersSchool of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, United Kingdom.ORCID https://orcid.org/0000-0002-3794-967X

Funding

C150 ChairsCanada Research Chairs Tier II ChairCIHR Project GrantConsejo Nacional de Ciencia y Tecnología 748435Engineering and Physical Sciences Research Council EP/N509619/1Natural Sciences and Engineering Research Council of Canada Discovery GrantUniversity of Victoria Graduate FellowshipUniversity of Victoria Nanotherapeutics Aspiration Cluster
6 · The paper itself

Abstract

Stealth precision polymer nanofibers show great promise as therapeutic delivery systems. However, existing systems are largely limited to poly(ethylene glycol) (PEG) and suffer from challenging functionalization, hampering their translation. This work develops a modular, easily functionalizable platform for biocompatible stealth nanofibers based on a combination of ring-opening polymerisation (ROP), photoinduced electron/energy transfer reversible addition-fragmentation chain transfer (PET-RAFT) polymerisation, and crystallization-driven self-assembly (CDSA). Low length-dispersity poly(fluorenetrimethylenecarbonate)-b-poly(N-(2-hydroxypropyl) methacrylamide) (PFTMC-b-PHPMA) nanofibers may be produced in a single-step via CDSA, with a length that is dependent on the PHPMA DP

Indexed as

NanofibersPolymersCrystallizationHumansNanoparticlesPolyethylene GlycolsPolymerizationPolyethylene GlycolsPolymersMicellesNanomedicineOxygen-tolerant polymerizationPolymersSelf-assembly

Identifiers

PMID39994427
PMCPMC12015387

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.