ArticleScientific reports2025
Organ-specific accumulation and toxicity analysis of orally administered polyethylene terephthalate microplastics.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Fluorescent Labeling Strategies for Tracking Micro- and Nanoplastics in Biological Systems.Materials (Basel, Switzerland) · 2026Review
- Persistence of Polycyclic Aromatic Hydrocarbons and Microplastics: A Serious Alarm to Human Health and Ecosystems.Chemical record (New York, N.Y.) · 2026Review
- Mechanistic Insights into PET-MPs-Aggravated Ischemic Stroke via Integrated Computational-Experimental Approaches.Environmental science & technology · 2026Article
- Respiratory risks of microplastics and nanoplastics: Where? What? How?Innovation (Cambridge (Mass.)) · 2026Review
- Hepatotoxic Mechanisms of Polyethylene Terephthalate Microplastics Revealed by Network Toxicology, Molecular Docking, and In Vivo Validation.International journal of molecular sciences · 2026Article
- Small particles, large questions: unravelling the toxicity and potential health risks of PET micro-/nanoplastics.Particle and fibre toxicology · 2026Review
- Effects of microplastic on submerged nanofiltration for advanced drinking water treatment.Scientific reports · 2026Article
- Article
- FTIR based assessment of microplastic contamination in soil water and insect ecosystems reveals environmental and ecological risks.Scientific reports · 2025Article
- A conceptual enzyme-cell therapy model to aid microplastic clearance from the vitreous humor.Frontiers in bioengineering and biotechnology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Microplastics (MPs), plastic particles with a diameter of < 5 mm, are intentionally produced or formed by the breakdown of a variety of larger plastics. Polyethylene terephthalate (PET) is a common source of MPs and PET-MPs are prevalent in the environment. Owing to their persistence, PET-MPs can enter ecosystems, air, and food sources, posing significant health risks. This study aimed to investigate the toxicological effects and in vivo accumulation of PET-MPs smaller than 10 µm. To track their biodistribution, fluorescently labeled PET-MPs were prepared. Particle size and morphology were confirmed using physical and chemical characterization. Following the oral administration of PET-MPs in ICR (CD-1®) outbred mice, accumulation occurred predominantly in lungs, as confirmed by IVIS spectrum CT analysis and in vivo and ex vivo imaging. Toxicity assays revealed the development of granulomatous inflammation in the lungs at medium and high doses, indicating a concentration-dependent response. The recorded no-observed-adverse-effect levels were 1.75 mg/kg for males and 7 mg/kg for females. This study highlights the potential of PET-MPs to induce persistent inflammation in respiratory tissues and reveals the need for further research to support the regulatory standards and long-term health effects of MP exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.