Evidence map›Paper›PMID 39994332›Full record

ArticleScientific reports2025

Mechanism of calcitonin gene related peptide against acute pancreatitis in rats by modulating amino acid metabolism based on metabonomics.

Jian-Xiong Hu, Ying-Kai Chen, Shi-Jun Chen, Yan-Ya Lin, Jun-Nian Chen, Ying Xie, Cheng-Fei Zhao, Cun-Rong Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jian-Xiong HuDepartment of Critical Care Medicine, Fujian Medical University Union Hospital, Fuzhou, China.
Ying-Kai ChenThe School of Clinical Medicine, Fujian Medical University, Fuzhou, China.
Shi-Jun ChenDepartment of Critical Care Medicine, Affiliated Hospital of Putian University, Putian, China.
Yan-Ya LinDepartment of Critical Care Medicine, Affiliated Hospital of Putian University, Putian, China.
Jun-Nian ChenDepartment of Critical Care Medicine, Fujian Medical University Union Hospital, Fuzhou, China.
Ying XieSchool of Mechanical, Electrical and Information Engineering, Putian University, Putian, China.
Cheng-Fei ZhaoSchool of Pharmacy and Medical Technology, Putian University, Putian, China.
Cun-Rong ChenDepartment of Critical Care Medicine, Fujian Medical University Union Hospital, Fuzhou, China. chcr789@139.com.

Funding

National Natural Science Foundation of China 62276146Natural Science Foundation of Fujian Province 2023J011707Natural Science Foundation of Fujian Province 2023J011721
6 · The paper itself

Abstract

To study the mechanism of calcitonin gene related peptide(CGRP) protecting acute pancreatitis based on metabolomics. 24 adult male rats were randomly divided into control group (Con), acute pancreatitis model group (AP), CGRP treatment group (CGRP + AP, abbreviated as CGRP) and CGRP antagonist(CGRP(8-37)) pretreatment group (preCGRP(8-37) + AP, abbreviated as CGRP37), with 6 rats in each group. After different interventions, pancreases of rats in each group were collected for pathological analysis, and serum was collected for metabolomics analysis. Pathological examination of the pancreas suggested that the inflammation of pancreatitis in AP group was significant, the inflammation of pancreatitis in CGRP group was significantly reduced, and the pancreatitis in CGRP37 group was aggravated. Metabolomics of rat serum suggested that the differences in metabolites in each group were mainly related to amino acid metabolism, coenzyme/vitamin metabolism, carbohydrate metabolism, lipid metabolism, digestive system and other metabolic pathways. According to the trend of metabolite changes, we found 6 differential metabolites that were significantly correlated with CGRP intervention, including L-Valine, 5-Aminopentanoic acid, 4-oxo-L-proline, L-glutamine, L-proline, and Ornithine, all of which were related to amino acid metabolism. CGRP can effectively protect acute pancreatitis, possibly by regulating amino acid metabolism to alleviate acute pancreatitis.

Indexed as

Amino AcidsCalcitonin Gene-Related PeptideMetabolomicsPancreatitisPeptide FragmentsAcute DiseaseAnimalsDisease Models, AnimalMaleMetabolomePancreasRatsRats, Sprague-DawleyAmino AcidsCalcitonin Gene-Related Peptidecalcitonin gene-related peptide (8-37)Peptide FragmentsAcute pancreatitisAmino acidCGRPMetabolomics

Identifiers

PMID39994332
PMCPMC11850807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.