Evidence map›Paper›PMID 39994296›Full record

ArticleScientific reports2025

Integrated in vitro, in silico, and in vivo approaches to elucidate the antidiabetic mechanisms of Cicer arietinum and Hordeum vulgare extract and secondary metabolites.

Asif Shahzad, Wenjing Liu, Shoukat Hussain, Yueli Ni, Kun Cui, Yijian Sun, Xiangjie Liu, Qiuxin Duan, Jiaojiao Xia, Jinshan Zhang and 5 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. ADMET & DMPK · 2026
    Review
  8. Polyherbal Therapeutics Mitigate CClReproductive sciences (Thousand Oaks, Calif.) · 2025
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Asif Shahzad *Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, 1168 Yuhua Road, Chenggong, Kunming, 650500, Yunnan, People's Republic of China.
Wenjing Liu *Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, 1168 Yuhua Road, Chenggong, Kunming, 650500, Yunnan, People's Republic of China.
Shoukat Hussain *Departments of Biochemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Yueli Ni *Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, 1168 Yuhua Road, Chenggong, Kunming, 650500, Yunnan, People's Republic of China.
Kun CuiDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, 1168 Yuhua Road, Chenggong, Kunming, 650500, Yunnan, People's Republic of China.
Yijian SunDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, 1168 Yuhua Road, Chenggong, Kunming, 650500, Yunnan, People's Republic of China.
Xiangjie LiuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, 1168 Yuhua Road, Chenggong, Kunming, 650500, Yunnan, People's Republic of China.
Qiuxin DuanDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, 1168 Yuhua Road, Chenggong, Kunming, 650500, Yunnan, People's Republic of China.
Jiaojiao XiaDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, 1168 Yuhua Road, Chenggong, Kunming, 650500, Yunnan, People's Republic of China.
Jinshan ZhangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, 1168 Yuhua Road, Chenggong, Kunming, 650500, Yunnan, People's Republic of China.
Zhe XuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, 1168 Yuhua Road, Chenggong, Kunming, 650500, Yunnan, People's Republic of China.
Buqing SaiDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, 1168 Yuhua Road, Chenggong, Kunming, 650500, Yunnan, People's Republic of China.
Yuechun ZhuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, 1168 Yuhua Road, Chenggong, Kunming, 650500, Yunnan, People's Republic of China.
Qiao ZhangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, 1168 Yuhua Road, Chenggong, Kunming, 650500, Yunnan, People's Republic of China. zhangqiao200824@126.com.
Zhe YangDepartments of Pathology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Wuhua, , Kunming, 650032, Yunnan, People's Republic of China. zyangpku@163.com.

Funding

National Natural Science Foundation of China (No. 82203565, 82103388, 81960462, 31960145)Science and technology innovation team of tumor metabolism research, Kunming Medical University (CXTD202102)Yunnan province applied research funds (202201AY070001-011, 202201AY070001-043, 202201AS070077, 202201AY070001-150)
6 · The paper itself

Abstract

Diabetes mellitus is a group of metabolic disorders that can lead to severe health problems, and the current treatments often have harmful side effects. Therefore, there is a growing interest in discovering new antidiabetic drugs with fewer adverse effects, and natural products are a promising source for this purpose. Cicer arietinum and Hordeum vulgare are plants with high levels of phytochemicals that have been shown to have therapeutic properties. This study investigates the anti-diabetic potential of C. arietinum and H. vulgare seeds and their secondary metabolites. We employed a comprehensive approach combining in vitro, in silico, and in vivo methods to evaluate the efficacy of the compounds. Our findings reveal that the extracts of C. arietinum (IC

Indexed as

CicerDiabetes Mellitus, ExperimentalHordeumHypoglycemic AgentsPlant Extractsalpha-Amylasesalpha-GlucosidasesAnimalsComputer SimulationGlycoside Hydrolase InhibitorsMaleMiceMolecular Docking SimulationSecondary Metabolismalpha-Amylasesalpha-GlucosidasesGlycoside Hydrolase InhibitorsHypoglycemic AgentsPlant ExtractsDiabetes mellitusDocking studiesDruggabilityHepatoprotective effectMedicagolMolecular dynamics simulationsPhytochemicalsSTZ-induced mice

Identifiers

PMID39994296
PMCPMC11850774

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.