ArticleNPJ biofilms and microbiomes2025
Irrigation of the intramedullary channel improves outcome of DAIR in a sheep model.
Article in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Translation-driven design: development of an antibiotic-loaded hydrogel for the management of orthopaedic device-related infection.Bioactive materials · 2026Article
- Estimation of Ewe Live Weight and Carcass Traits Using Advanced Hybrid Deep Learning and Multimodal Feature Fusion.Biology · 2026Article
- [Sensor-based monitoring of fracture healing].Unfallchirurgie (Heidelberg, Germany) · 2025Article
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Authors and funding
14 authors.
Funding
Abstract
The management of fracture-related infection (FRI) with Debridement, Antibiotics, Irrigation, and Implant Retention (DAIR) is an appealing option, but its suitability is restricted to a relatively narrow proportion of patients. This study aimed to create a large animal model of DAIR after FRI and to evaluate outcomes after early (2 weeks) and delayed (5 weeks) DAIR. Additionally, intramedullary lavage (IML) of the intramedullary canal (IMC) is introduced as a novel technique to remove infected tissue. Our findings showed that DAIR failed to resolve infections in both early and delayed groups, whilst IML significantly reduced bacterial counts, leading to culture-negative results in the soft tissue and bone marrow. IML did not compromise long-term bone healing as revealed by an implant load sensor on the plate. In conclusion, DAIR was successfully achieved in a new large animal model with minimal losses. The IML method improves treatment efficacy, potentially broadening the range of patients suitable for DAIR.
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Registered trials
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