ArticleNature communications2025
Insights from a methylome-wide association study of antidepressant exposure.
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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Effects of 6-months of SSRI use on DNA-methylation and gene expression in blood.Brain, behavior, and immunity · 2026Trial
- The non-linear and linear effects of CYP2C19 metaboliser status on DNA methylation: a methylome-wide association study.Clinical epigenetics · 2026Article
- Multi-ancestry epigenome wide association study of generalized anxiety disorder.medRxiv : the preprint server for health sciences · 2026Article
- Epigenetic profiles of response to transcranial magnetic stimulation in treatment resistant depression.BMC medical genomics · 2025Article
- Insights from a methylome-wide association study of antidepressant exposure.Nature communications · 2025Article
- A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison.Nature. Mental health · 2025Article
- Intermediate endophenotypes and epigenetic mechanisms of psychiatric disorders.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Immune-inflammatory, neuroplastic, and epigenetic effects of electroconvulsive therapy in mood disorders: an overview of recent studies.Frontiers in psychiatry · 2025Review
Corrections and comments
- Update of
Authors and funding
42 authors.
E DavysonDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-7313-0530
X ShenDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0538-4774
F HuiderComplex Trait Genetics, Center of Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7776-7988
M J AdamsDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-3599-6018
K BorgesDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
D L McCartneyInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-3242-0360
L F BarkerInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, 4072, Australia.ORCID http://orcid.org/0000-0003-3356-5625
J van DongenComplex Trait Genetics, Center of Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
D I BoomsmaComplex Trait Genetics, Center of Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7099-7972
A WeihsDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475, Greifswald, Germany.ORCID http://orcid.org/0000-0002-7113-0027
H J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475, Greifswald, Germany.
L KühnDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475, Greifswald, Germany.ORCID http://orcid.org/0000-0002-0158-8286
A TeumerDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475, Greifswald, Germany.ORCID http://orcid.org/0000-0002-8309-094X
H VölzkeGerman Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, 17489, Greifswald, Germany.
T ZhuInstitute for Molecular Medicine Finland FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.
J KaprioInstitute for Molecular Medicine Finland FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-3716-2455
M OllikainenInstitute for Molecular Medicine Finland FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-3661-7400
F S DavidInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0001-9521-5669
S MeinertInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
F SteinDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
A J ForstnerInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-1876-6368
U DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
T KircherDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-2514-2625
A TapucMax Planck School of Cognition, Leipzig, Germany.ORCID http://orcid.org/0009-0001-8567-2011
D CzamaraMax-Planck-Institute of Psychiatry, Department Genes and Environment, Munich, Germany.ORCID http://orcid.org/0000-0001-7381-904X
E B BinderMax-Planck-Institute of Psychiatry, Department Genes and Environment, Munich, Germany.ORCID http://orcid.org/0000-0001-7088-6618
T BrücklMax-Planck-Institute of Psychiatry, Department Genes and Environment, Munich, Germany.
A S F KwongDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
P YousefiMedical Research Council Integrative Epidemiology Unit at the University of Bristol, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-3284-3240
C C Y WongSocial, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
L ArseneaultSocial, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-2938-2191
H L FisherSocial, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-4174-2126
J MillDepartment of Clinical & Biomedical Sciences, University of Exeter Medical School, University of Exeter, Exeter, UK.ORCID http://orcid.org/0000-0003-1115-3224
S R CoxLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-4036-3642
P RedmondLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
T C RussDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-9797-2188
E J C G van den OordCenter for Biomarker Research and Precision Medicine (BPM), Virginia Commonwealth University, Virginia, USA.ORCID http://orcid.org/0000-0003-2701-4405
K A AbergCenter for Biomarker Research and Precision Medicine (BPM), Virginia Commonwealth University, Virginia, USA.ORCID http://orcid.org/0000-0001-6103-5168
B W J H PenninxDepartment of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7779-9672
R E MarioniInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-4430-4260
N R WrayInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, 4072, Australia.ORCID http://orcid.org/0000-0001-7421-3357
A M McIntoshDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. andrew.mcintosh@ed.ac.uk.ORCID http://orcid.org/0000-0002-0198-4588
Funding
The development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6MDevelopmental methylomics of autism spectrum disorderR01MH124981 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI ABERG, KAROLINA ANNA, VAN DEN OORD, EDWIN · 2021 to 2025
$3.4MA GENOME-WIDE METHYLATION STUDY ON ESSENTIAL HYPERTENSIONR01HL104125 · NHLBI · AUGUSTA UNIVERSITY · PI WANG, XIAOLING · 2011 to 2015
$2.9MA longitudinal methylome study to detect biomarkers predicting MDD trajectoriesR01MH099110 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI VAN DEN OORD, EDWIN · 2013 to 2017
$2.9MADOLESCENT ALCOHOL ABUSE: A TWIN-STUDY PERSPECTIVER37AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2000 to 2009
$2.9MNeuropsychological and genomic signatures of violence exposure in childhoodR01HD077482 · NICHD · DUKE UNIVERSITY · PI CASPI, AVSHALOM · 2013 to 2018
$2.8M1/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109528 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2016 to 2020
$2.5MTwin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3MAdolescent Alcohol Abuse: A Twin-Study PerspectiveR01AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2013 to 2017
$1.2MBEHAVIORAL PRECURSORS OF ALCOHOLISM--TWIN FAMILY STUDIESR01AA009203 · NIAAA · INDIANA UNIVERSITY BLOOMINGTON · PI ROSE, RICHARD JOSEPH · 1994 to 1998
–USE &ABUSE OF ALCOHOL--A BEHAVIOR-GENETICS PERSPECTIVEK05AA000145 · NIAAA · INDIANA UNIVERSITY BLOOMINGTON · PI ROSE, RICHARD JOSEPH · 1992 to 1996
–Academy of Finland (Suomen Akatemia) 100499Academy of Finland (Suomen Akatemia) 118555Academy of Finland (Suomen Akatemia) 141054Academy of Finland (Suomen Akatemia) 205585Academy of Finland (Suomen Akatemia) 251316Academy of Finland (Suomen Akatemia) 263278Academy of Finland (Suomen Akatemia) 264146Academy of Finland (Suomen Akatemia) 307339Academy of Finland (Suomen Akatemia) 308248Academy of Finland (Suomen Akatemia) 328685Age UK [Disconnected Mind project]Age UK Disconnected Mind projectDepartment of Health | National Health and Medical Research Council (NHMRC) 1113400Department of Health | National Health and Medical Research Council (NHMRC) 1173790EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 847776EPA EP-C-15-001Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) 480-15-001/674NHLBI NIH HHS R01 HL104125NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K05 AA000145NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R01 AA015416NIAAA NIH HHS R37 AA012502NICHD NIH HHS R01 HD077482NIMH NIH HHS R01 MH099110NIMH NIH HHS R01 MH124981NIMH NIH HHS U01 MH109528RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/W008793/1RCUK | Economic and Social Research Council (ESRC) ES/S012567/1RCUK | Medical Research Council (MRC) EP/S02431X/1RCUK | Medical Research Council (MRC) MR/R024065/1Royal Society 221890/Z/20/ZSigrid Juséliuksen Säätiö (Sigrid Jusélius Foundation) 1057Sigrid Juséliuksen Säätiö (Sigrid Jusélius Foundation) #1105U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH124981Wellcome TrustWellcome Trust (Wellcome) 220857/Z/20/ZWellcome Trust (Wellcome) 226770/Z/22/ZWellcome Trust (Wellcome) 227063/Z/23/Z
Abstract
This study tests the association of whole-blood DNA methylation and antidepressant exposure in 16,531 individuals from Generation Scotland (GS), using self-report and prescription-derived measures. We identify 8 associations and a high concordance of results between self-report and prescription-derived measures. Sex-stratified analyses observe nominally significant increased effect estimates in females for four CpGs. There is observed enrichment for genes expressed in the Amygdala and annotated to synaptic vesicle membrane ontology. Two CpGs (cg15071067; DGUOK-AS1 and cg26277237; KANK1) show correlation between DNA methylation with the time in treatment. There is a significant overlap in the top 1% of CpGs with another independent methylome-wide association study of antidepressant exposure. Finally, a methylation profile score trained on this sample shows a significant association with antidepressant exposure in a meta-analysis of eight independent external datasets. In this large investigation of antidepressant exposure and DNA methylation, we demonstrate robust associations which warrant further investigation to inform on the design of more effective and tolerated treatments for depression.
Indexed as
Antidepressive AgentsDepressionDNA MethylationEpigenomeAdultAgedCpG IslandsFemaleGenome-Wide Association StudyHumansMaleMiddle AgedScotlandSelf ReportAntidepressive Agents
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