Evidence map›Paper›PMID 39994203›Full record

ArticleNature communications2025

Drop-shaped microgrooves guide unidirectional cell migration for enhanced endothelialization.

Xing-Wang Wang, Cheng-Qiang Ye, Qian Tang, Hong-Mei Yu, Jing Wang, Guo-Sheng Fu, Ke-Feng Ren, Lu Yu, Jian Ji

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xing-Wang WangMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0002-8231-0760
Cheng-Qiang YeMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.
Qian TangKey Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Hong-Mei YuDepartment of Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Jing WangMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.
Guo-Sheng FuKey Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Ke-Feng RenMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China. renkf@zju.edu.cn.ORCID http://orcid.org/0000-0001-5456-984X
Lu YuKey Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China. jyulu@zju.edu.cn.ORCID http://orcid.org/0000-0002-2057-8841
Jian JiMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China. jijian@zju.edu.cn.ORCID http://orcid.org/0000-0001-9870-4038

Funding

National Natural Science Foundation of China (National Science Foundation of China) U20A20262Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) LD22E030008
6 · The paper itself

Abstract

Atrial fibrillation (AF) significantly increases the risk of ischemic stroke, and in non-valvular AF, 90% of stroke-causing thrombi arise from the left atrial appendage (LAA). Percutaneous LAA occlusion using an occluder is a crucial clinical intervention. However, occluder materials could provoke thrombi, termed device-related thrombosis (DRT), leading to treatment failure. Rapid endothelialization is essential to address the DRT but the occluder's large surface area and irregular cell migration on the surface impede this process. Here, we report a continuous drop-shaped microgroove, which has a drop-shaped unit structure similar to endothelial cells. The microgrooves polarize the cytoskeleton, guiding cell unidirectional migration within the grooves, and increase cell migration efficiency. We show that drop-shaped microgrooves accelerate wound healing in a rat model, and that occluder discs with drop-shaped microgrooves promote endothelialization in a canine model. Together, our results show that integrating microgrooves with medical devices is a promising approach for addressing DRT.

Indexed as

Atrial FibrillationCell MovementAnimalsAtrial AppendageCytoskeletonDisease Models, AnimalDogsEndothelial CellsHumansMaleRatsRats, Sprague-DawleyThrombosisWound Healing

Identifiers

PMID39994203
PMCPMC11850906

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.