Evidence map›Paper›PMID 39994191›Full record

ArticleNPJ Parkinson's disease2025

Early detection of Parkinson's disease through multiplex blood and urine biomarkers prior to clinical diagnosis.

Shuo Gao, Zheng Wang, Yuanfeng Huang, Guang Yang, Yijing Wang, Yan Yi, Qiao Zhou, Xingxing Jian, Guihu Zhao, Bin Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Multitype hand writing as a digital marker for Parkinson's disease.Clinical parkinsonism & related disorders · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shuo Gao *National Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Zheng Wang *National Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0000-0002-8388-6139
Yuanfeng HuangNational Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Guang YangNational Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Yijing WangNational Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Yan YiBioinformatics Center, Xiangya Hospital & Furong Laboratory, Central South University, Changsha, 410008, Hunan, China.
Qiao ZhouNational Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Xingxing JianNational Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Guihu ZhaoNational Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Bin LiNational Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Linyong XuHunan Provincial Key Laboratory of Oral Health Research & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, China.
Kun XiaNational Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Beisha TangKey Laboratory of Hunan Province in Neurodegenerative Disorders, Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.ORCID http://orcid.org/0000-0003-2120-1576
Jinchen LiNational Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China. lijinchen@csu.edu.cn.ORCID http://orcid.org/0000-0001-5522-806X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blood and urine biomarkers are commonly used to diagnose and monitor chronic diseases. We initially screened 67 biomarkers, including 4 urine biomarkers and 63 blood biomarkers, and identified 13 blood biomarkers significantly associated with Parkinson's disease (PD). Among these, we discovered three novel markers demonstrating strong associations: phosphate (P = 1.81 × 10

Identifiers

PMID39994191
PMCPMC11850829

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.