Evidence map›Paper›PMID 39994182›Full record

ArticleThe pharmacogenomics journal2025

CYP3A5 and POR gene polymorphisms as predictors of infection and graft rejection in post-liver transplant patients treated with tacrolimus - a cohort study.

Graziella D' Agostino Ribeiro Naldi, Ariane Boccoli Minari, Thales D M Pereira, Victor Fossaluza, Nicholas Wagner Eugenio, Marcelo Alves Ferreira, Guilherme H Gregório, Lucas Nacif, Luiz Augusto Carneiro D Albuquerque, Ricardo di Lazzaro Filho and 2 more

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Article in The pharmacogenomics journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Graziella D' Agostino Ribeiro NaldiDepartment of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil. grazi.dago.santos@gmail.com.ORCID 0000-0002-9440-8255
Ariane Boccoli MinariDepartment of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil.
Thales D M PereiraInstitute of Mathematics and Statistics of the University of São Paulo, São Paulo, Brazil.
Victor FossaluzaInstitute of Mathematics and Statistics of the University of São Paulo, São Paulo, Brazil.
Nicholas Wagner EugenioInstitute of Mathematics and Statistics of the University of São Paulo, São Paulo, Brazil.ORCID 0009-0006-2549-1311
Marcelo Alves FerreiraCell Biology Laboratory, University of São Paulo School of Medicine, São Paulo, Brazil.
Guilherme H GregórioFaculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-8379-0452
Lucas NacifDepartment of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil.
Luiz Augusto Carneiro D AlbuquerqueDepartment of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil.
Ricardo di Lazzaro FilhoFounder & co-CEO at Genera, São Paulo, Brazil.
Eduardo Luiz Rachid CançadoDepartment of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil.
Suzane Kioko OnoDepartment of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo (São Paulo Research Foundation) 2019/00945-1Fundação de Amparo à Pesquisa do Estado de São Paulo (São Paulo Research Foundation) 2022/05586-2Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (National Council for Scientific and Technological Development) 308609/2018-2
6 · The paper itself

Abstract

Liver transplantation is the only curative option for patients with advanced stages of liver disease, with tacrolimus used as the immunosuppressive drug of choice. Genetic variability can interfere with drug response, potentially leading to overexposure or underexposure. This study aims to investigate the association of CYP3A4 (rs2740574, rs2242480, rs35599367), CYP3A5 (rs776746, rs10264272), POR (rs1057868) and ABCB1 (rs1128503, rs2229109, rs9282564) gene polymorphisms with infection, acute rejection, and renal failure. The logistic regression model found an influence of CYP3A5 (rs776746) and POR28 (rs1057868) on the development of acute rejection after liver transplantation (p = 0.028). It also found an association between carriers of the variant allele of the POR*28 gene and infection.

Indexed as

Cytochrome P-450 CYP3AGraft RejectionImmunosuppressive AgentsInfectionsLiver TransplantationPolymorphism, Single NucleotideTacrolimusAdultCohort StudiesCytochrome P-450 Enzyme SystemFemaleHumansMaleMiddle AgedCYP3A5 protein, humanCytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemImmunosuppressive AgentsPOR protein, humanTacrolimus

Identifiers

PMID39994182

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.