Evidence map›Paper›PMID 39994111›Full record

ReviewForensic science, medicine, and pathology2025

Invasive aspergillosis leading to fatal cerebral hemorrhage: a case report and comprehensive literature review.

Nicole Pasin, Matteo Lorenzoni, Erika Velotta, Giulio Riva, Raffaella Scotto Opipari, Mara Di Pietro, Roberta Tamiozzo, Umberto Nardi

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Forensic science, medicine, and pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicole PasinDepartment of Prevention Health, Section of Legal Medicine, Ospedale San Bortolo, Viale Ferdinando Rodolfi 37, Vicenza, 36100, Italy.
Matteo LorenzoniDepartment of Diagnostic and Public Health, Section of Forensic Medicine, University of Verona, P.le L.A. Scuro 10, Verona, 37134, Italy. matteo.lorenzoni@studenti.univr.it.ORCID http://orcid.org/0009-0006-8760-959X
Erika VelottaDepartment of Diagnostic and Public Health, Section of Forensic Medicine, University of Verona, P.le L.A. Scuro 10, Verona, 37134, Italy.
Giulio RivaDepartment of Diagnostic, Pathology Unit and Health and Risk Management, Ospedale San Bortolo, Viale Ferdinando Rodolfi 37, Vicenza, 36100, Italy.
Raffaella Scotto OpipariDepartment of Imaging, Oncological Neuroradiology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, 00146, Italy.
Mara Di PietroDepartment of Prevention Health, Section of Neuroscience, Ospedale San Bortolo, Viale Ferdinando Rodolfi 37, Vicenza, 36100, Italy.
Roberta TamiozzoDepartment of Prevention Health, Section of Legal Medicine, Ospedale San Bortolo, Viale Ferdinando Rodolfi 37, Vicenza, 36100, Italy.
Umberto NardiDepartment of Prevention Health, Section of Legal Medicine, Ospedale San Bortolo, Viale Ferdinando Rodolfi 37, Vicenza, 36100, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aspergillus fumigatus significantly threatens immunocompromised individuals by causing potentially fatal diseases, primarily invasive aspergillosis (IA). IA, mostly affecting the lungs, can disseminate to other organs, including the central nervous system (CNS), leading to high mortality rates. We present the case of an 84-year-old immunocompetent male with a history of significant comorbidities, who developed a lethal subarachnoid and tetraventricular hemorrhage. Initial symptoms included paroxysmal neuralgic pain and ophthalmic manifestations. Despite diagnostic efforts, the infection was confirmed only after a positive Aspergillus galactomannan antigen test on cerebrospinal fluid, post-mortem microbiological culture, and mass spectrometry (MS) authentication. The patient exhibited rapid deterioration and succumbed due to the erosion of a mycotic cerebral aneurysm of the left internal carotid artery. Diagnosing IA, particularly isolated CNS IA in immunocompetent patients, is challenging due to its nonspecific symptoms and difficulty detecting the pathogen in standard diagnostic tests. This article emphasizes the pivotal role of pathological examination to obtain a definitive diagnosis, assess fungal infiltration of brain vessels, and thus clarify the accurate source of fatal brain hemorrhages.

Indexed as

AspergillosisCerebral HemorrhageNeuroaspergillosisSubarachnoid HemorrhageAged, 80 and overAntigens, FungalAspergillus fumigatusCarotid Artery, InternalFatal OutcomeGalactoseHumansIntracranial AneurysmMaleMannansAntigens, FungalgalactomannanGalactoseMannansBrain hemorrhageClinical autopsyFungal infectionInvasive aspergillosisMycotic aneurismVascular complications

Identifiers

PMID39994111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.