Evidence map›Paper›PMID 39994084›Full record

ArticleNeurosurgical review2025

Epilepsy as primary tumor manifestation correlates with patient status, age, and tumor volume but not with survival in elderly glioblastoma patients: a retrospective bicentric analysis.

Matthias Demetz, Constantin Hecker, Hamza Adel Salim, Aleksandrs Krigers, Jürgen Steinbacher, Lukas Machegger, Johannes Kerschbaumer, Melanie Buchta, Johannes Pöppe, Philipp Geiger and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Matthias DemetzDepartment of Neurosurgery, Medical University of Innsbruck, Anichstr. 35, AT-6020, Innsbruck, Austria.
Constantin HeckerDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Ignaz-Harrer-Strasse 79, AT-5020, Salzburg, Austria.
Hamza Adel SalimDepartment of Medicine, An-Najah National University, Nablus, Palestine.
Aleksandrs KrigersDepartment of Neurosurgery, Medical University of Innsbruck, Anichstr. 35, AT-6020, Innsbruck, Austria.
Jürgen SteinbacherDepartment of Neuroradiology, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Lukas MacheggerDepartment of Neuroradiology, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Johannes KerschbaumerDepartment of Neurosurgery, Medical University of Innsbruck, Anichstr. 35, AT-6020, Innsbruck, Austria.
Melanie BuchtaDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Ignaz-Harrer-Strasse 79, AT-5020, Salzburg, Austria.
Johannes PöppeDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Ignaz-Harrer-Strasse 79, AT-5020, Salzburg, Austria.
Philipp GeigerDepartment of Neurosurgery, Medical University of Innsbruck, Anichstr. 35, AT-6020, Innsbruck, Austria.
Antonio SpinelloDepartment of Neurosurgery, Medical University of Innsbruck, Anichstr. 35, AT-6020, Innsbruck, Austria.
Theo F J KrausInstitute of Pathology, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Christoph J GriessenauerDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Ignaz-Harrer-Strasse 79, AT-5020, Salzburg, Austria.
Claudius ThoméDepartment of Neurosurgery, Medical University of Innsbruck, Anichstr. 35, AT-6020, Innsbruck, Austria.
Christian F FreyschlagDepartment of Neurosurgery, Medical University of Innsbruck, Anichstr. 35, AT-6020, Innsbruck, Austria.
Christoph SchwartzDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Ignaz-Harrer-Strasse 79, AT-5020, Salzburg, Austria. c.schwartz@salk.at.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assessment of the potential impact of epilepsy as primary tumor manifestation on survival in elderly glioblastoma multiforme (GBM) patients. Two academic neurosurgical centers retrospectively analyzed all GBM patients aged 65 years and older with de-novo tumors, who underwent surgery between 2006 and 2021. Epidemiological, histopathological, imaging and survival data were obtained from patients' electronic charts, and screened for the presence of epilepsy preoperatively and during follow-up. Patient status was assessed by the Karnofsky Performance Scale (KPS), epilepsy was evaluated using the Engel classification. Patients were categorized in an epilepsy cohort (i.e. patients with epilepsy as primary GBM manifestation, and a reference cohort (i.e. patients with no initial epilepsy). This study analyzed 451 GBM patients (55% males); median age at tumor diagnosis was 73 years. The epilepsy cohort was younger (71.0 vs. 74.0 year; p = 0.001), had better KPS (80 vs. 70; p = 0.039), and had smaller tumors (127 vs. 221 cm

Indexed as

Brain NeoplasmsEpilepsyGlioblastomaAgedAged, 80 and overAge FactorsFemaleHumansKarnofsky Performance StatusMaleNeurosurgical ProceduresRetrospective StudiesTumor BurdenElderlyEpilepsyGlioblastomaOutcomeSeizures

Identifiers

PMID39994084
PMCPMC11850559

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.