Evidence map›Paper›PMID 39994021›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

ImmunoPET imaging of Trop2 expression in triple-negative breast cancer using [

Wenpeng Huang, Yuwei Zhang, Xiaoyan Xiao, Qi Yang, Jason C Mixdorf, Xinyao Sun, Jonathan W Engle, Yu Fan, Liming Li, Lei Kang and 1 more

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Article
  3. Review
  4. Trop-2.2-Directed Radioimmunotherapy with 177Lu, 225Ac, and 212Pb in a Pancreatic Cancer Model.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  5. TROP2-targeted NIR-II fluorescence imaging for visualizing surgical margins and metastatic sentinel lymph nodes in breast cancers.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. Noninvasive ImmunoPET imaging of PD-L1 expression in non-small cell lung cancer and bladder cancer using [Colloids and surfaces. A, Physicochemical and engineering aspects · 2025
    Article
  9. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. [American journal of nuclear medicine and molecular imaging · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wenpeng HuangDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 Xishiku Str., Xicheng Dist., Beijing, 100034, China.
Yuwei ZhangDepartment of Nuclear Medicine, Peking Union Medical College Hospital, Beijing, 100730, China.
Xiaoyan XiaoDepartment of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China.
Qi YangDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 Xishiku Str., Xicheng Dist., Beijing, 100034, China.
Jason C MixdorfDepartments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, 53705, USA.
Xinyao SunDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 Xishiku Str., Xicheng Dist., Beijing, 100034, China.
Jonathan W EngleDepartments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, 53705, USA.
Yu FanDepartment of Urology, Peking University First Hospital, No. 8 Xishiku Str., Xicheng Dist., Beijing, 100034, China. Dantefanbmu@pku.edu.cn.
Liming LiDepartment of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China. perfect1989a@163.com.
Lei KangDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 Xishiku Str., Xicheng Dist., Beijing, 100034, China. kanglei@bjmu.edu.cn.
Weibo CaiDepartments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, 53705, USA. wcai@uwhealth.org.ORCID 0000-0003-4641-0833

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Beijing Municipal Science & Technology Commission Z221100007422027Beijing Nova Program 20240484725Henan Medical Science and Technology Research Program Joint Construction Project LHGJ20220409National High Level Hospital Clinical Research Funding 2023IR17, 2024IR07National Key Research and Development Program of China 2024YFE0113500NCI NIH HHS P30 CA014520Scientific and Technological Achievements Transformation Incubation Guidance Fund Project of Peking University First Hospital 2024CX18The Henan Association for Science and Technology Youth Talent Support Program 2023HYTP039The Key Research Project in Henan Universities 23A320059the National Natural Science Foundation of China 82472018, 82171970the Scientific and technological project in Henan Province 242102311026
6 · The paper itself

Abstract

purposeThe Trop2-targeting antibody-drug conjugate (ADC) sacituzumab govitecan (Trodelvy) has demonstrated remarkable efficacy in patients with metastatic triple-negative breast cancer (TNBC). ImmunoPET imaging offers a noninvasive method to visualize the expression and distribution of target antigens in vivo. In this study, we developed F(ab') MATERIALS AND

methodsTrodelvy-F(ab')

resultsThe radiochemical yield of [

conclusionsOur findings indicate that [

Indexed as

Antigens, NeoplasmCell Adhesion MoleculesCopper RadioisotopesGene Expression Regulation, NeoplasticHeterocyclic CompoundsHeterocyclic Compounds, 1-RingImmunoconjugatesImmunoglobulin Fab FragmentsPositron Emission Tomography Computed TomographyTriple Negative Breast NeoplasmsAnimalsAntibodies, Monoclonal, HumanizedCamptothecinCell Line, TumorFemaleHumans1,4,7-triazacyclononane-N,N',N''-triacetic acidAntibodies, Monoclonal, HumanizedAntigens, NeoplasmCamptothecinCell Adhesion MoleculesCopper-64Copper RadioisotopesHeterocyclic CompoundsHeterocyclic Compounds, 1-RingImmunoconjugatesImmunoglobulin Fab Fragmentssacituzumab govitecanTACSTD2 protein, humanAntibody-drug conjugateCu-64F(ab')2 fragmentImmunoPETTriple-negative breast cancerTrodelvyTrop2

Identifiers

PMID39994021
PMCPMC12221780

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.