ArticleWorld journal of surgery2025
Predictive Value of the Red Cell Distribution Width-To-Albumin Ratio for Clinical Outcomes in Patients With Peptic Ulcer Perforation.
Article in World journal of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The association between the red cell distribution width to serum albumin ratio and erectile dysfunction in American adults: A cross-sectional National Health and Nutrition Examination Survey analysis from 2001 to 2004.The Journal of international medical research · 2026Article
- Red cell distribution width-to-albumin ratio and hypertension risk: age-specific threshold effects identified in the 2017-2020 NHANES U.S. Adult population.BMC cardiovascular disorders · 2025Article
- Risk factors and predictive model construction for severe complications following repair of perforated peptic ulcer.Frontiers in surgery · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeptic ulcer perforation is a potentially life-threatening complication of peptic ulcer disease. Several scoring systems have been developed to predict outcomes in these patients. The red cell distribution width-to-albumin ratio (RAR) has shown promise as a prognostic marker in various conditions, yet its role in peptic ulcer perforation remains unclear. This study aimed to evaluate the predictive value of RAR in patients with peptic ulcer perforation.
methodsThis retrospective study was conducted between 2016 and 2024 on patients who underwent surgery for peptic ulcer perforation. Patient demographics, clinical features, laboratory values, and surgical outcomes were analyzed. The main outcomes were major postoperative complications and 30-day mortality. Multivariate regression analysis was used to identify independent predictors of these outcomes. The ability of RAR to predict outcomes was also assessed.
resultsThe study included 187 patients with a median age of 49.7 years, of whom 78.6% were males. Major complications occurred in 18.1% of the patients and the 30-day mortality rate was 9.6%. Multivariate analysis identified age, surgical delay, elevated C-reactive protein and RAR as independent predictors of major complications. For 30-day mortality, only age and RAR remained significant in the multivariate model. Receiver operating characteristic curve analysis showed that RAR had high diagnostic accuracy for predicting both major complications (AUC = 0.883) and mortality (AUC = 0.944).
conclusionWith its high sensitivity and specificity for predicting major complications and mortality in patients with peptic ulcer perforation, RAR has significant potential as a prognostic marker in conjunction with traditional risk factors in clinical practice.
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