ArticleAJNR. American journal of neuroradiology2025
The Effect of Diagnostic Hypercapnic Cerebrovascular Reactivity Imaging on Vital Signs and Acute and Follow-Up Ischemic Adverse Events in Patients with Flow-Limiting Intracranial Arterial Stenosis.
Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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11 authors.
Funding
Abstract
background and purposeAnatomical imaging is a hallmark for visualizing chronic and acute infarcts but provides incomplete information on stroke risk. Respiratory hypercapnic gas challenges show promise for noninvasively assessing hemodynamic function and mapping cerebrovascular reserve capacity, an indicator of how near parenchyma is to exhausting autoregulatory capacity. However, limited safety information exists for this method in high-risk patients with flow-limiting stenosis. This study reports on the physiologic changes and adverse events (AEs) following diagnostic hypercapnic cerebrovascular reactivity imaging assessments. MATERIALS AND
methodsBetween January 2011 and May 2024, reactivity scans were performed on 262 patients. In patients with flow-limiting intracranial arterial steno-occlusion (>70%), vital signs were assessed during a twice-repeated three-minute fixed-inspired 5%CO
results129 patients met criteria for flow-limiting arterial steno-occlusion. Blood pressure did not change (
conclusionsFindings support the use of hypercapnic reactivity mapping in the setting of flow-limiting cerebrovascular disease.
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