Evidence map›Paper›PMID 39993755›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Acute Kidney Injury and Fanconi Syndrome Caused by a Red Yeast Rice Supplement.

Toshiki Doi, Akira Shimizu, Emi Morimoto, Kenichi Morii, Aiko Okubo, Sonoo Mizuiri, Yoshiko Nishizawa, Takao Masaki

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Toshiki DoiDepartment of Nephrology, Ichiyokai Harada Hospital, Japan.
Akira ShimizuDepartment of Analytic Human Pathology, Nippon Medical School, Japan.
Emi MorimotoDepartment of Nephrology, Ichiyokai Harada Hospital, Japan.
Kenichi MoriiDepartment of Nephrology, Ichiyokai Harada Hospital, Japan.
Aiko OkuboDepartment of Nephrology, Ichiyokai Harada Hospital, Japan.
Sonoo MizuiriDepartment of Nephrology, Ichiyokai Harada Hospital, Japan.
Yoshiko NishizawaDepartment of Nephrology, Ichiyokai Harada Hospital, Japan.
Takao MasakiDepartment of Nephrology, Hiroshima University Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report a case of acute kidney injury and Fanconi syndrome associated with a red yeast rice supplement. A 72-year-old woman's serum creatinine rose from 0.7 to 3.97 mg/dL after starting the supplement, accompanied by metabolic acidosis, proteinuria, hematuria, and glucosuria. A kidney biopsy showed proximal tubular injury without abundant tubulitis. Immunostaining showed dilated tubules that were positive for CD 10, confirming proximal tubule localization. Discontinuation of the supplement and steroid pulse therapy improved the patient's condition. This case highlights the health risks associated with unregulated dietary supplementation.

Indexed as

Acute Kidney InjuryBiological ProductsDietary SupplementsFanconi SyndromeAgedFemaleHumansBiological Productsred yeast riceacute kidney injuryChinese herb nephropathyFanconi syndromeproximal tubule injurypuberulic acidred yeast rice

Identifiers

PMID39993755
PMCPMC12425577

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.