ArticleThe Journal of veterinary medical science2025
In vitro susceptibility of differentiated SH-SY5Y human neuroblastoma cells to herpes simplex virus type 1 and Japanese encephalitis virus infection.
Article in The Journal of veterinary medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Differentiated LUHMES Cells as a Model to Investigate Neurotropic Arboviruses and Evaluate Host-Directed Therapeutics.Microorganisms · 2026Article
- Time-Resolved Transcriptomic Profiling of Chandipura Virus Infection Reveals Dynamic Host Responses and Host-Directed Therapeutic Targets.International journal of molecular sciences · 2026Article
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Authors and funding
6 authors.
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Abstract
This study aimed to investigate the effects of cell differentiation status and neurotropic viral infectivity on the susceptibility of undifferentiated and differentiated SH-SY5Y cells to herpes simplex virus type 1 (HSV-1) and Japanese encephalitis virus (JEV) infections. Notably, undifferentiated SH-SY5Y cells were susceptible to both HSV-1 and JEV infections. However, differentiated cells exhibiting a phenotypically mature neuron-like morphology and markedly increased neuronal marker levels showed low susceptibility to JEV infection. Overall, these findings suggest that SH-SY5Y cells become more resistant to JEV infection as they mature. This cell culture model is useful to elucidate the molecular mechanisms regulating the maturation state-specific resistance of neurons to JEV.
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