Evidence map›Paper›PMID 39993512›Full record

ArticleInternational journal of pharmaceutics2025

Mechanistic studies on pH-permeability relationships: Impact of the membrane polar headgroup region on pKa.

Md Hridoy, Irfan Khan, Mercy Ramanjulu, Paul Anthony, Wayne Childers, Swati Nagar, Ken Korzekwa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Improving the Estimation of pThe journal of physical chemistry. B · 2026
    Article
  2. Recent Advances in Oral Drug Delivery Systems for BCS III Drugs.Current issues in molecular biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Md HridoyDepartment of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA; Current address: Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
Irfan KhanMoulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, PA 19140, USA.
Mercy RamanjuluDepartment of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA; Current address: Recombination Therapeutics, Pennsylvania Biotechnology Center, Doylestown, PA 18902, USA.
Paul AnthonyDepartment of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA.
Wayne ChildersDepartment of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA.
Swati NagarDepartment of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA.
Ken KorzekwaDepartment of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA. Electronic address: korzekwa@temple.edu.

Funding

Predicting Intracellular Drug Concentrations In The Presence Of TransportersR01GM104178 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI Kenneth Ray Korzekwa, Swati Nagar · 2013 to 2026
$4.0M
Improving prediction of drug interactions mediated by time-dependent inhibitorsR01GM114369 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI KORZEKWA, KENNETH RAY, NAGAR, SWATI · 2016 to 2023
$3.2M
NIGMS NIH HHS R01 GM104178NIGMS NIH HHS R01 GM114369
6 · The paper itself

Abstract

Passive permeability through biological membranes requires partitioning of drug molecules into the lipid bilayer and subsequent permeation. Most drugs are weak acids or bases, making their ionization constants (pK

Indexed as

Cell Membrane PermeabilityCaco-2 CellsHexanesHumansHydrogen-Ion ConcentrationPermeabilityPharmaceutical PreparationsPhosphatidylcholinesHexanesn-hexanePharmaceutical PreparationsPhosphatidylcholinesCaco-2 cells, Diacetyl phosphatidylcholineMembraneModeling and simulationPermeabilitypH partitioning

Identifiers

PMID39993512
PMCPMC11949092

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.