Evidence map›Paper›PMID 39993455›Full record

Observational studyBone2025

Acute pain trajectories in elderly patients with fragility hip fractures.

Paul Potnuru, Christina Goehl, Katherine S Becker, Alejandro Juul, Madison Aycock, Johanna Blair de Haan, Sudipta Sen, Michelle Ge, Stephen J Warner, Nadia Hernandez

Abstract readObservational Study
In one paragraph

Observational study in Bone, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Paul PotnuruDepartment of Anesthesiology, Critical Care and Pain Medicine, McGovern Medical School at UTHealth Houston, Houston, TX, United States of America. Electronic address: paul.potnuru@uth.tmc.edu.
Christina GoehlDepartment of Anesthesiology, Critical Care and Pain Medicine, McGovern Medical School at UTHealth Houston, Houston, TX, United States of America.
Katherine S BeckerAnesthesia Partners of Colorado, Vail, CO, United States of America.
Alejandro JuulDepartment of Anesthesiology, The Warren Alpert Medical School of Brown University, Providence, RI, United States of America.
Madison AycockMcGovern Medical School at UTHealth Houston, Houston, TX, United States of America.
Johanna Blair de HaanDepartment of Anesthesiology, Critical Care and Pain Medicine, McGovern Medical School at UTHealth Houston, Houston, TX, United States of America.
Sudipta SenDepartment of Anesthesiology, Critical Care and Pain Medicine, McGovern Medical School at UTHealth Houston, Houston, TX, United States of America.
Michelle GeDepartment of Anesthesiology, Critical Care and Pain Medicine, McGovern Medical School at UTHealth Houston, Houston, TX, United States of America.
Stephen J WarnerDepartment of Orthopedic Surgery, McGovern Medical School at UTHealth Houston, Houston, TX, United States of America.
Nadia HernandezDepartment of Anesthesiology, Critical Care and Pain Medicine, McGovern Medical School at UTHealth Houston, Houston, TX, United States of America.

Funding

AIM-AHEAD Coordinating Center - All Four CoresOT2OD032581 · OD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Paul Avillach, Bettina M. Beech · 2021 to 2026
$168.7M
Research Training of Anesthesiology Physician-ScientistsT32GM135118 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Holger K. Eltzschig, Cynthia Ju · 2022 to 2026
$1.1M
NIGMS NIH HHS T32 GM135118NIH HHS OT2 OD032581
6 · The paper itself

Abstract

backgroundPain management for hospitalized elderly patients with fragility hip fractures (FHF) remains challenging. This study aims to distinguish acute pain trajectories in FHF patients that can inform personalized analgesia management.

methodsWe conducted a prospective observational study of patients aged 65 and older with FHF at a Level I trauma center. The primary outcome was daily average pain assessed for five days post-injury using the Brief Pain Inventory (BPI). We used group-based trajectory modeling (GBTM) to distinguish acute pain trajectories. Then, factors and secondary outcomes (opioid use and hospital length of stay [LOS]) associated with more severe pain trajectories were identified.

resultsWe enrolled 100 consecutive patients with FHF between June 2022 and June 2023. We identified three distinct acute pain trajectories: minimal pain, subsiding pain, and persistent pain. Factors associated with more severe pain trajectories included higher initial pain on admission (OR 1.17, 95 % CI 1.02-1.36, P = 0.047), higher BMI (OR 1.15, 95 % CI 1.02-1.29, P = 0.021), and intertrochanteric fracture type (OR = 6.46, 95 % CI 1.49-27.98, P = 0.013). The persistent pain trajectory was significantly associated with 40 % more opioid use (P = 0.01) and a longer LOS (LOS ratio = 1.45, 95 % CI 1.21-1.74, P < 0.001).

conclusionAcute pain in FHF patients can be classified into distinct trajectories, providing a basis for personalized pain management. More severe pain trajectories are associated with higher opioid use and longer length of hospital stay.

Indexed as

Acute PainHip FracturesAgedAged, 80 and overAnalgesics, OpioidFemaleHumansLength of StayMalePain ManagementPain MeasurementProspective StudiesAnalgesics, OpioidAcute painElderly patientsFragility hip fractureGroup-based trajectory modelingOpioid usePain trajectoriesPersonalized pain management

Identifiers

PMID39993455
PMCPMC12065541

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.