Evidence map›Paper›PMID 39993450›Full record

ArticleAntiviral research2025

Oral 4'-fluorouridine rescues mice from advanced lymphocytic choriomeningitis virus infection.

Jonna B Westover, Kie Hoon Jung, Shuli Mao, Alexander A Kolykhalov, Gregory R Bluemling, Michael G Natchus, George R Painter, Brian B Gowen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antiviral research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jonna B WestoverInstitute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA.
Kie Hoon JungInstitute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA.
Shuli MaoEmory Institute for Drug Development, Emory University, Atlanta, GA, USA.
Alexander A KolykhalovEmory Institute for Drug Development, Emory University, Atlanta, GA, USA.
Gregory R BluemlingEmory Institute for Drug Development, Emory University, Atlanta, GA, USA.
Michael G NatchusEmory Institute for Drug Development, Emory University, Atlanta, GA, USA.
George R PainterEmory Institute for Drug Development, Emory University, Atlanta, GA, USA; Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA, USA; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, USA.
Brian B GowenInstitute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA. Electronic address: brian.gowen@usu.edu.

Funding

Task B6: In Vitro Assessment for Antimicrobial Activity Against Respiratory Viruses, Including SARS-CoV-275N93019D00021 · NIAID · UTAH STATE UNIVERSITY · PI JULANDER, JUSTIN · 2019 to 2025
$7.3M
NIAID NIH HHS 75N93019D00021NIAID NIH HHS HHSN272201700041I
6 · The paper itself

Abstract

Lymphocytic choriomeningitis virus (LCMV) can cause severe, life-threatening infection and disease in organ transplant recipients and other immunocompromised individuals. Additionally, significant developmental and neurological disabilities, vision impairments, and miscarriages can occur as a direct result of LCMV infection during pregnancy. Currently, there are no approved antiviral drugs to protect at-risk populations. Here, we report on the potent in vitro activity of the 4'-fluorouridine (4'-FlU) ribonucleoside analog against several strains of LCMV, with EC

Indexed as

Antiviral AgentsLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusUridineAdministration, OralAnimalsDisease Models, AnimalFemaleHumansMiceMice, Inbred C57BLAntiviral AgentsUridine4'fluorouridineArenavirusEIDD-2749Lymphocytic choriomeningitis virusMammarenavirus

Identifiers

PMID39993450
PMCPMC12009201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.