Evidence map›Paper›PMID 39993308›Full record

Observational studyJMIR mental health2025

Patterns of Skills Review in Smartphone Cognitive Behavioral Therapy for Depression: Observational Study of Intervention Content Use.

Emily E Bernstein, Katharine E Daniel, Peyton E Miyares, Susanne S Hoeppner, Kate H Bentley, Ivar Snorrason, Lauren B Fisher, Jennifer L Greenberg, Hilary Weingarden, Oliver Harrison and 1 more

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in JMIR mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05386329 (Development and Preliminary Testing of a Non-regulated Digital Service That Supports Cognitive Behavioral Therapy for Depressive Symptoms Under Clinical Supervision), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05386329 nacompletednot on this map

Development and Preliminary Testing of a Non-regulated Digital Service That Supports Cognitive Behavioral Therapy for Depressive Symptoms Under Clinical Supervision

TypeinterventionalSponsorMassachusetts General HospitalRan2022 to 2023Enrolled28ConditionsMajor Depressive DisorderArmsMindset: Therapist-guided smartphone-delivered CBT
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emily E Bernstein *Massachusetts General Hospital, Boston, MA, United States.ORCID 0000-0001-8609-3153
Katharine E Daniel *Massachusetts General Hospital, Boston, MA, United States.ORCID 0000-0002-4371-2740
Peyton E MiyaresMassachusetts General Hospital, Boston, MA, United States.ORCID 0009-0007-6803-9648
Susanne S HoeppnerMassachusetts General Hospital, Boston, MA, United States.ORCID 0000-0003-2060-1666
Kate H BentleyMassachusetts General Hospital, Boston, MA, United States.ORCID 0000-0002-6875-6440
Ivar SnorrasonMassachusetts General Hospital, Boston, MA, United States.ORCID 0000-0002-5979-3151
Lauren B FisherMassachusetts General Hospital, Boston, MA, United States.ORCID 0000-0003-4670-2457
Jennifer L GreenbergMassachusetts General Hospital, Boston, MA, United States.ORCID 0000-0002-2919-3673
Hilary WeingardenMassachusetts General Hospital, Boston, MA, United States.ORCID 0000-0002-3448-3755
Oliver HarrisonKoa Health, London, United Kingdom.ORCID 0000-0001-6947-2581
Sabine WilhelmMassachusetts General Hospital, Boston, MA, United States.ORCID 0000-0002-5316-2711

Funding

Digital Monitoring of Agitation for Short-Term Suicide Risk PredictionK23MH120436 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BENTLEY, KATE H. · 2019 to 2024
$1.0M
Smartphone-based digital phenotyping to detect high-risk affect states in body dysmorphic disorderK23MH119372 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI WEINGARDEN, HILARY · 2019 to 2024
$922k
NIMH NIH HHS K23 MH119372NIMH NIH HHS K23 MH120436Wellcome Trust
6 · The paper itself

Abstract

backgroundSmartphones could enhance access to effective cognitive behavioral therapy (CBT). Users may frequently and flexibly access bite-size CBT content on personal devices, review and practice skills, and thereby achieve better outcomes.

objectiveWe explored the distribution of actual interactions participants had with therapeutic content in a trial of smartphone CBT for depression and whether interactions were within assigned treatment modules or revisits to prior module content (ie, between-module interactions).

methodsWe examined the association between the number of within- and between-module interactions and baseline and end-of-treatment symptom severity during an 8-week, single-arm open trial of a therapist-guided CBT for depression mobile health app.

resultsInteractions were more frequent early in treatment and modestly declined in later stages. Within modules, most participants consistently made more interactions than required to progress to the next module and tended to return to all types of content rather than focus on 1 skill. By contrast, only 15 of 26 participants ever revisited prior module content (median number of revisits=1, mode=0, IQR 0-4). More revisits were associated with more severe end-of-treatment symptom severity after controlling for pretreatment symptom severity (P<.05).

conclusionsThe results suggest that the frequency of use is an insufficient metric of engagement, lacking the nuance of what users are engaging with and when during treatment. This lens is essential for developing personalized recommendations and yielding better treatment outcomes.

trial registrationClinicalTrials.gov NCT05386329; https://clinicaltrials.gov/study/NCT05386329?term=NCT05386329.

Indexed as

Cognitive Behavioral TherapyDepressionMobile ApplicationsSmartphoneAdultFeasibility StudiesFemaleHumansMaleMiddle AgedTelemedicineTreatment Outcomeappcognitive behavioral therapydepressiondigital healthengagementmental healthmHealthMindsetmobile healthmobile phonesmartphone

Identifiers

PMID39993308
PMCPMC11894344

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.