ArticlePancreas2025
Hypophosphatemia as a Predictor of Pancreatic Necrosis in Acute Alcohol-induced Pancreatitis.
Article in Pancreas, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Breaking the Calcium Overload Cycle in Acute Pancreatitis: Emerging Pharmacological Strategies.Digestive diseases and sciences · 2026Review
- Divergent associations of phosphate levels with organ failure between ICU and non-ICU populations with acute pancreatitis.BMC gastroenterology · 2026Article
- Admission hyperphosphatemia as a predictor of severity and mortality in acute pancreatitis: A 1000-patient cohort study.World journal of gastrointestinal surgery · 2026Article
- Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePancreatic necrosis is a catastrophic complication of acute pancreatitis and is associated with increased morbidity and mortality. While there is no objective means to predict pancreatic necrosis, recent studies have identified serum phosphate levels as a contributor to the disease process, with worse outcomes noted in patients with low serum phosphates. We aimed to determine if there was a relationship between low serum phosphate levels and the risk of developing pancreatic necrosis in patients with acute alcoholic pancreatitis (AAP).
methodsHealth care records from patients admitted between January 2017 and December 2022 for acute alcoholic pancreatitis were retrospectively reviewed. These patients were categorized based on their phosphate levels within 48 hours of admission: normal phosphate levels (2.8-4.5 mg/dL) and hypophosphatemia (<2.8 mg/dL). Imaging findings from hospital stays were examined to identify cases of pancreatic necrosis. These cases were then compared across patients with normal and low phosphate levels.
resultsAmong the 207 patients admitted for acute alcoholic pancreatitis, 67 met the inclusion and exclusion criteria. Of these, 37 patients exhibited serum phosphate levels below 2.8 mg/dL, while 30 maintained levels between 2.8 and 4.5 mg/dL within the first 48 hours of admission. Of the patients in the hypophosphatemia group, 27.02% were noted to develop pancreatic necrosis during hospital stay compared to only 6.66% in the normal phosphate group ( P value: 0.029). In addition, those who developed necrosis had an overall lower mean phosphate level of 2.13 mg/dL compared to the mean phosphate level of 2.60 mg/dL ( P value: 0.0521) in patients without necrosis. The median duration of hospital stay ( P value: 0.65) and rate of intensive care unit (ICU) admission ( P value: 0.41) were similar in both groups.
conclusionsEarly hypophosphatemia during admission for AAP was associated with an increased risk of developing pancreatic necrosis; however, it may not affect the overall length of hospital stay or rate of ICU admission.
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