SynthesisThe Journal of invasive cardiology2025
Combined atherectomy and intravascular lithotripsy in calcified coronary lesions: a meta-analysis.
Synthesis in The Journal of invasive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Coronary Calcified Nodules: From Pathological Definitions to Intravascular Imaging- and Morphology-Guided PCI.International journal of molecular sciences · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivesStudies exploring the feasibility and safety of combined atherectomy and intravascular lithotripsy (IVL) for treatment of severely calcified coronary lesions are limited. The authors aimed to study the pooled evidence for the safety and efficacy of this combined approach in severely calcified coronary lesions and evaluate its clinical and procedural outcomes.
methodsOnline databases were searched for studies using combined atherectomy (rotational, orbital, or excimer laser) and IVL during PCI for calcified coronary lesions. The outcomes of interest were acute procedural success, periprocedural complications, and cardiovascular (CV) events. Pooled proportions with 95% CI were calculated using a random-effects model.
resultsA total of 12 observational studies with 720 patients were included. The mean age was 73 years, 76% were men, and 48% of the patients had an acute coronary syndrome. The pooled procedural success rate of combined atherectomy and IVL was 93% (95% CI, 89.56-96.25). Coronary perforation occurred in 2.9% (95% CI, 1.76-4.36) of the cases. Over a mean follow-up of 111 days, the incidence of CV outcomes was myocardial infarction 2.0% (95% CI, 0.67-3.93), stroke 1.4% (95% CI, 0.36-3.14), target vessel revascularization 2.2% (95% CI, 1.01-3.79), stent thrombosis 1.1% (95% CI, 0.21-2.84), major bleeding 5.8% (95% CI, 0.00-21.40), CV death 3.6% (95% CI, 1.53-6.42), and all-cause death 4.8% (95% CI, 2.75-7.33).
conclusionsCombined atherectomy and IVL for calcified coronary lesions is feasible with a high procedural success rate. However, there is a low but meaningful risk of procedural complications including coronary perforations, and a low risk of adverse CV events.
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