Evidence map›Paper›PMID 39993202›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The AaFoxA factor regulates female reproduction through chromatin remodeling in the mosquito vector Aedes aegypti.

Yang Cheng, Xuesong Wang, Yike Ding, Houhong Zhang, Zhenyu Jia, Alexander S Raikhel

Abstract read
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In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yang ChengDepartment of Entomology and Institute of Integrative Genome Biology, University of California, Riverside, CA 92521.
Xuesong WangInterdepartmental Graduate Program of Genetics, Genomics and Bioinformatics, University of California, Riverside, CA 92521.
Yike DingDepartment of Entomology and Institute of Integrative Genome Biology, University of California, Riverside, CA 92521.
Houhong ZhangDepartment of Entomology and Institute of Integrative Genome Biology, University of California, Riverside, CA 92521.
Zhenyu JiaDepartment of Botany and Plant Sciences, University of California, Riverside, CA 92521.
Alexander S RaikhelDepartment of Entomology and Institute of Integrative Genome Biology, University of California, Riverside, CA 92521.

Funding

MOLECULAR BASIS OF ECDYSTEROID ACTION IN THE MOSQUITOR01AI036959 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI RAIKHEL, ALEXANDER SIMEON, ROY, SOURAV · 1995 to 2022
$10.0M
The role of mosquito microRNAs in blood digestion.R01AI113729 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI RAIKHEL, ALEXANDER SIMEON · 2014 to 2023
$4.1M
NIAID NIH HHS R01 AI036959NIAID NIH HHS R01 AI113729
6 · The paper itself

Abstract

Female mosquitoes are vectors of many devastating human diseases because they require blood feeding to initiate reproduction. Thus, elucidation of molecular mechanisms managing female mosquito reproduction is essential. Although the regulation of gene expression during the mosquito gonadotrophic cycle has been studied in detail, how this process is controlled at the chromatin level remains unclear. Chromatin must be accessible for transcription factors (TFs) governing gene expression. A specialized class of TFs, called pioneer factors (PFs), binds and remodels closed chromatin, permitting other TFs to bind DNA and activate the gene expression. Here, we identified a homolog of the vertebrate PF FoxA in the mosquito

Indexed as

AedesChromatin Assembly and DisassemblyInsect ProteinsMosquito VectorsTranscription FactorsAnimalsChromatinFemaleHistonesOvaryReproductionChromatinHistonesInsect ProteinsTranscription Factorschromatin remodelingCRISPR-Cas9histone modificationpioneer factortranscription

Identifiers

PMID39993202
PMCPMC11892592

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.