ArticleProceedings of the National Academy of Sciences of the United States of America2025
RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
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Who cites it
28 citing papers in PubMed.
- Metabolic sensor AMPK licenses intestinal CD103Science advances · 2026Article
- Article
- Peri-weaning, diet-induced activation of an IFNγ-mediated regulatory circuit promotes cDC1 maturation and CD8Nature communications · 2026Article
- ACY-1215 ameliorates experimental colitis by inhibiting dendritic cell maturation and Th1/Th17 responses.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- B7 costimulation antagonizes RORγt+ regulatory T cells and immune tolerance in the intestine.The Journal of experimental medicine · 2026Article
- Pan-cancer single-cell atlases of mouse and human tumor-associated dendritic cells.Nature communications · 2026Article
- Article
- Murine Intestinal Neonatal and Adult Dendritic Cell Subset Migration and Activation Characteristics in Response to Toll-Like Receptor Stimulation Through MyD88.Scandinavian journal of immunology · 2026Article
- The development of innate lymphoid cells.Nature immunology · 2026Review
- RORγtNature communications · 2026Article
- RORγtScience immunology · 2026Article
- Specialized Dendritic Cells Mediating Peripheral Tolerance to Intestinal Antigens.Immunological reviews · 2026Review
- DC subsets and states unraveled across human juxtatumoral and malignant tissues.Nature immunology · 2026Article
- Metabolic crosstalk between intestinal microbiota and dendritic cells: from homeostasis to inflammation.Acta biochimica et biophysica Sinica · 2025Review
- Heterogeneity of the intestinal mononuclear phagocyte compartment in health and inflammatory bowel disease.Science immunology · 2025Article
- Diet Components, Immune Function and IgE-Mediated Food Allergy.Nutrients · 2025Review
- Single-cell multiomics data integration and generation with scPairing.Cell reports methods · 2025Article
- Review
- Dendritic Cells: Orchestrators of Immune Responsiveness and Tolerance.Immunological reviews · 2025Review
- Ontogenetic Diversification of Type 2 Conventional Dendritic Cells in the Bone Marrow: A Central Logic for Peripheral Immunity.Immunological reviews · 2025Review
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Authors and funding
30 authors.
Hamsa NarasimhanInstitute for Immunology, Biomedical Center Munich, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried 82152, Germany.
Maria L RichterBiomedical Center, Physiological Chemistry, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried 82152, Germany.
Ramin ShakibaInstitute for Immunology, Biomedical Center Munich, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried 82152, Germany.
Nikos E PapaioannouBiomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried 82152, Germany.
Christina StehleInstitute for Medical Immunology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin 10117, Germany.
Kaushikk Ravi RengarajanInstitute for Immunology, Biomedical Center Munich, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried 82152, Germany.
Isabel UlmertSection for Experimental and Translational Immunology, Institute for Health Technology, Technical University of Denmark, Kongens Lyngby 2800, Denmark.
Arek KendirliInstitute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried 82152, Germany.
Clara de la RosaInstitute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried 82152, Germany.
Pin-Yu KuoInstitute for Immunology, Biomedical Center Munich, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried 82152, Germany.
Abigail AltmanMolecular Medicine and Gene Therapy, Lund Stem Cell Centre, Lund University, Lund 221 84, Sweden.ORCID 0009-0002-9692-2976
Philipp MünchInstitute for Molecular Medicine and Research Center for Immunotherapy (Forschungszentrum für Immuntherapie), University Medical Center Johannes Gutenberg-University Mainz, Mainz 55131, Germany.ORCID 0009-0004-1289-6833
Saba MahboubiInstitute for Molecular Medicine and Research Center for Immunotherapy (Forschungszentrum für Immuntherapie), University Medical Center Johannes Gutenberg-University Mainz, Mainz 55131, Germany.ORCID 0000-0001-9029-8784
Vanessa KüntzelBiomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried 82152, Germany.
Amina SayedInstitute for Immunology, Biomedical Center Munich, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried 82152, Germany.
Eva-Lena StangeInstitute of Medical Microbiology, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen 52074, Germany.ORCID 0000-0001-8277-0663
Jonas PesInstitute of Medical Microbiology, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen 52074, Germany.
Alina Ulezko AntonovaDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110.
Carlos-Filipe PereiraMolecular Medicine and Gene Therapy, Lund Stem Cell Centre, Lund University, Lund 221 84, Sweden.ORCID 0000-0002-9724-1382
Ludger KleinInstitute for Immunology, Biomedical Center Munich, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried 82152, Germany.
Diana DudziakInstitute of Immunology, Jena University Hospital of the Friedrich-Schiller-University, Jena 07747, Germany.ORCID 0000-0001-9358-134X
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0001-5222-4987
Natalia TorowInstitute of Medical Microbiology, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen 52074, Germany.ORCID 0000-0003-3013-8724
Mathias W HornefInstitute of Medical Microbiology, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen 52074, Germany.ORCID 0000-0001-6096-9110
Björn E ClausenInstitute for Molecular Medicine and Research Center for Immunotherapy (Forschungszentrum für Immuntherapie), University Medical Center Johannes Gutenberg-University Mainz, Mainz 55131, Germany.ORCID 0000-0002-2484-7842
Martin KerschensteinerInstitute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried 82152, Germany.
Katharina LahlSection for Experimental and Translational Immunology, Institute for Health Technology, Technical University of Denmark, Kongens Lyngby 2800, Denmark.
Chiara RomagnaniInstitute for Medical Immunology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin 10117, Germany.
Maria Colomé-TatchéBiomedical Center, Physiological Chemistry, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried 82152, Germany.
Barbara U SchramlInstitute for Immunology, Biomedical Center Munich, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried 82152, Germany.ORCID 0000-0002-5801-0151
Funding
Deutsche Forschungsgemeinschaft (DFG) CRC1292/2-TP20 (Project Nr. 318346496)Deutsche Forschungsgemeinschaft (DFG) DU548/6-1 (project number 431402787)Deutsche Forschungsgemeinschaft (DFG) FOR2599 (project P03 SCHR 1444/2-1)Deutsche Forschungsgemeinschaft (DFG) SFB 1335/P08 - Project number 360372040Deutsche Forschungsgemeinschaft (DFG) TRR355/1-A09 (Project Nr. 490846870)Deutsche Forschungsgemeinschaft (DFG) TRR 359 - Project number 491676693Deutsche Forschungsgemeinschaft (DFG) TRR 374/1 2024 TP B07 (project number 509149993)EC | ERC | HORIZON EUROPE European Research Council (ERC) ERC-2016-STG-715182
Abstract
Conventional dendritic cells (cDCs) are potent antigen-presenting cells (APCs) that integrate signals from their environment allowing them to direct situation-adapted immunity. Thereby they harbor great potential for being targeted in vaccination, autoimmunity, and cancer. Here, we use fate mapping, functional analyses, and comparative cross-species transcriptomics to show that RORγt
Indexed as
Antigen-Presenting CellsDendritic CellsNuclear Receptor Subfamily 1, Group F, Member 3AIRE ProteinAnimalsCD4-Positive T-LymphocytesHumansMiceMice, Inbred C57BLTranscription FactorsAIRE ProteinNuclear Receptor Subfamily 1, Group F, Member 3Transcription FactorsAIREantigen presenting cellsdendritic cellsinnate lymphocytesRORγt
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.