ArticlePloS one2025
The alteration of uterine microbiota participated in the activation of the decidual inflammatory response in early spontaneous abortion.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Microbiota composition of the female reproductive tract and miscarriage: a systematic review and meta-analysis.NPJ biofilms and microbiomes · 2026Pooled it
- Complications Following Late Second-Trimester Dilatation and Evacuation: A Retrospective Cohort Comparison of Missed and Induced Abortions.International journal of women's health · 2026Article
- How microbiota influence maternal blood disorder in miscarriage.Molecular biology reports · 2025Review
- Targeting Decidual Macrophage Polarization through JNK Signaling Pathway Inhibition Alleviates Adverse Pregnancy Outcomes in Early Spontaneous Abortion.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly spontaneous abortion (ESA) is one of the most common clinically recognized pregnancy complications. While multiple factors such as embryo abnormalities and maternal conditions may contribute to ESA, early identification and screening of maternal risk factors are increasingly important to explore the potential etiologies and improve prevention and treatment strategies for ESA. This study investigates the changes in uterine microbiota and the decidual immune response in ESA patients without embryo abnormalities.
methodsESA patients without embryo abnormality and artificial abortion (AA) controls were enrolled for clinical characteristics analysis. The decidual endometrium was subsequently collected for histological evaluation and inflammatory indicator detection. Moreover, 16S rRNA gene sequencing of uterine secretions was performed to investigate the differences in uterine microorganisms between the ESA and AA groups.
resultsClinical analysis showed higher inflammatory response with elevated neutrophil counts in ESA patients. The increase in leukocytes, including neutrophils, was positively correlated with ESA. ESA patients presented significantly increased IL-1β expression in decidual stromal cells. 16S rRNA gene sequencing revealed greater diversity in the uterine microbiota of the ESA group, which presented decreased Lactobacillus abundance and increased abundance of other bacteria at the genus and species levels.
conclusionsChanges in the uterine microbiome are likely related to inflammatory response and lead to early pregnancy loss.
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