Validation and user experience testing of DataCryptChain: An open-source standard combining blockchain technology with asymmetric encryption for private, secure, shareable, and tamper-proof research data.

DataCryptChain is an open-source standard combining blockchain with advanced encryption ensuring research data remains private, secure, shareable, and tamper-proof. Ability to detect intentional tampering of data was measured, and user experience was evaluated. In this study, simulated datasets were randomized to be tampered with or not tampered with, and detection of tampering was measured. Volunteer's ability to complete assigned tasks using the software was evaluated. Among 10000 simulated datasets (4436 randomized to tampering) there was 100% sensitivity and specificity for detection. All volunteers successfully installed DataCryptChain and 5/6 completed their tasks. All participants were able to transmit data without ever exposing unencrypted data and with no need to share passwords. Several deficiencies in the user experience were noted. Importantly, the test users felt that although they would be willing to use DataCryptChain in practice, it would need a more user-friendly interface. This study demonstrates a novel algorithm using blockchain and asymmetric encryption that, although previously documented theoretically, has never been published as a working software package. While DataCryptChain has 100% sensitivity and specificity for detecting data tampering, further development is needed to improve the user experience.