Evidence map›Paper›PMID 39992941›Full record

ArticlePloS one2025

Histomorphology of placentae of women with sickle cell disease during pregnancy - A case control study.

Mohammed Mumuni, Kevin Kofi Adutwum-Ofosu, Benjamin Arko-Boham, Bismarck Afedo Hottor, Nii Koney-Kwaku Koney, Kwame Adu-Bonsaffoh, Samuel Antwi Oppong, Peter Ofori Appiah, John Ahenkorah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The human placenta development and anatomy.Archives of gynecology and obstetrics · 2026
    Review
  2. Review
  3. Diseases (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohammed MumuniDepartment of Anatomy, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle Bu Campus, Accra, Ghana.
Kevin Kofi Adutwum-OfosuDepartment of Anatomy, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle Bu Campus, Accra, Ghana.ORCID 0000-0002-3731-3399
Benjamin Arko-BohamDepartment of Anatomy, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle Bu Campus, Accra, Ghana.
Bismarck Afedo HottorDepartment of Anatomy, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle Bu Campus, Accra, Ghana.
Nii Koney-Kwaku KoneyDepartment of Anatomy, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle Bu Campus, Accra, Ghana.
Kwame Adu-BonsaffohDepartment of Obstetrics and Gynaecology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle Bu Campus, Accra, Ghana.
Samuel Antwi OppongDepartment of Obstetrics and Gynaecology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle Bu Campus, Accra, Ghana.ORCID 0000-0002-3836-1376
Peter Ofori AppiahDepartment of Medical Microbiology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle Bu Campus, Accra, Ghana.
John AhenkorahDepartment of Anatomy, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle Bu Campus, Accra, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSickle cell disease (SCD) is known to exert multifaceted effects on pregnancy, potentially influencing placental structure and function.

aimOur aim was to utilize stereology as a precise analytical tool to evaluate the histo-morphologic and functional changes in term placentae of women with SCD against those of non-SCD women.

methodA case control study was conducted at the Korle-Bu Teaching Hospital's labour unit and included 38 pregnant women, comprising 19 cases and 19 controls. Placenta samples were paired and matched with gestational age and taken at term (38 weeks + 2 weeks). Tissue sections were prepared, stained with hematoxylin and eosin, and volume densities of syncytial knots, foetal capillaries, syncytial denuded areas, and intervillous spaces estimated by stereological methods. Statistical analysis was performed to compare mean values between the SCD and control groups.

resultsAmong the study participants with SCD, 13.16% (5) had sickle cell haemoglobin S (HbSS), 34.21% (13) had haemoglobin C (HbSC) and 2.63% (1) had β-thalassemia (HbS). On stereological assessment, there were statistically significant differences in mean volume densities of syncytial knots (p = < 0.0034), foetal capillaries (p = < 0.0001), syncytial denudations (p = < 0.0028), and intervillous space (p = < 0.0113) between term placentae of women with SCD and those without SCD.

conclusionSCD placentae may result in a substantial increase in syncytial knot formation, possibly because of hypermaturation of the chorionic villi, significant increase in foetal capillaries potentially due to the hypoxic nature of the SCD placentae, syncytial denuded areas as a result of alteration of the placental syncytium and reduced intervillous spaces which may be due to villous congestion. These findings suggest the need for heightened monitoring of placental function and fetal well-being in pregnancies complicated by SCD to reduce adverse perinatal outcomes.

Indexed as

Anemia, Sickle CellPlacentaPregnancy Complications, HematologicAdultCase-Control StudiesFemaleHumansPregnancyYoung Adult

Identifiers

PMID39992941
PMCPMC11849815

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.