ArticlePloS one2025
Association between serum neurofilament light chains and Life's Essential 8: A cross-sectional analysis.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimSerum neurofilament light chain (sNfL), a protein released into the bloodstream post-neuronal axonal damage, has been validated as a robust biomarker for a range of neurological and systemic diseases. Concurrently, Life's Essential 8 (LE8) comprises a holistic suite of health behaviors and metabolic markers that are essential for assessing and enhancing cardiovascular health. Nevertheless, the interrelation between LE8 and sNfL is not yet fully elucidated. This investigation seeks to evaluate the association between LE8 and sNfL within the framework of the National Health and Nutrition Examination Survey (NHANES).
methodsAccording to data from the 2013-2014 NHANES, the study enrolled a total of 5262 participants aged between 20 and 75 years. We excluded 3035 individuals lacking sNfL measurements, included 2071 subjects for analysis, and further excluded cases from LE8 due to missing data. Ultimately, 1691 valid datasets were obtained. Hierarchical and multiple regression analyses were conducted, supplemented by smooth curve fitting and saturation effect analysis to investigate the relationship between LE8 and sNfL.
resultsAn inverse correlation was observed between LE8 scores and sNfL levels. For each SD change increase in LE8, log-transformed sNfL levels decreased by 0.14 (-0.17, -0.11 in the non-adjusted model), 0.08 (-0.10, -0.05 in the minimally adjusted model), and 0.08 (-0.12, -0.05 in the fully adjusted model). The multi-factor adjusted β coefficients and 95% confidence intervals (CIs) for LE8 categories (<50, 50 ~ 80, and ≥80) were as follows: reference, -0.20 (-0.34, -0.06), and -0.26 (-0.42, -0.10). The inflection point was determined to be 58.12, identified using a two-piece linear regression model.
conclusionThe analysis indicated a non-linear relationship between LE8 scores and sNfL levels. Associations were noted a positive association between LE8 and sNfL. These results suggest that lifestyle modifications and optimization of metabolic markers could potentially correlate with reduced sNfL levels; further investigation is necessary to confirm a causal relationship.
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