ArticleBrain : a journal of neurology2025
Epigenetic age acceleration in peripheral blood correlates with brain-MRI age acceleration.
Article in Brain : a journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Peripheral blood DNA methylation partially reports on immune cell type composition in the frontal brain.Brain, behavior, & immunity - health · 2026Article
- Article
- Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration.medRxiv : the preprint server for health sciences · 2026Article
- Morphological Changes of the Retina in Alcohol Use Disorder: A Systematic Review and Meta-analysis of Studies Using Optical Coherence Tomography.Indian journal of psychological medicine · 2025Review
- Intermediate endophenotypes and epigenetic mechanisms of psychiatric disorders.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- DNA methylation and prediction of biological age.Frontiers in molecular biosciences · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
As the world's population ages, more and more people are expected to suffer from age-related diseases. Biological ageing markers derived from DNA methylation and brain structure show promise in predicting health outcomes. Understanding the relationship between these biomarkers can promote the development of effective health interventions. In a sample of 254 participants from the Netherlands Twin Register (20-84 years), we investigated associations between DNA methylation age acceleration based on five epigenetic biomarkers (Hannum, Horvath, PhenoAge, GrimAge and DunedinPACE) and brain age acceleration based on neuroimaging (brainageR). Furthermore, we applied bivariate twin models to examine the contribution of genetic and environmental factors to the associations (cross-twin cross-trait correlations and within monozygotic-twin pair differences). We observed relationships with brain age acceleration for DNA methylation age acceleration based on the Hannum and GrimAge clocks that were supported by within monozygotic-twin pair difference modelling. Cross-twin cross-trait modelling confirmed a non-shared environmental aetiology. Twin analyses highlight the importance of the environment in accelerated ageing, raising the possibility for interventions such as lifestyle modification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.