ArticleJournal of cachexia, sarcopenia and muscle2025
Impact of Hydroxy-Methyl-Butyrate Supplementation on Malnourished Patients Assessed Using AI-Enhanced Ultrasound Imaging.
Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Evaluation of Muscle Mass and Quality With an AI-Based Muscle Ultrasound Imaging System in Patients at Risk of Malnutrition.Journal of cachexia, sarcopenia and muscle · 2025Observational
- Observational
- Artificial intelligence-assisted rectus femoris ultrasound vs. L3 computed tomography for sarcopenia assessment in oncology patients: establishing diagnostic cut-offs for muscle mass and quality.Frontiers in nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to evaluate the effects of an oral nutritional supplement (ONS) enriched with hydroxy-methyl-butyrate (HMB) in subjects with disease-related malnutrition (DRM) and to monitor these effects with an ultrasound Imaging System, based on artificial intelligence, in a real-world study.
methodsFifty consecutive adult patients with DRM were enrolled. The malnutrition was diagnosed by Global Leadership Initiative on Malnutrition (GLIM) criteria. For 3 months, the patients received nutritional education, and medical nutrition therapy was started with an adapted oral diet and two servings of an oral nutritional supplementation (ONS) with a hyperproteic hypercaloric formula (HMB-enriched). All patients were studied at baseline, and 3 months after intervention, with a nutritional assessment (anthropometry, bioelectrical impedanciometry [BIA], muscle ultrasonography and biochemical parameters). Ultrasound images were automatically quantified using an AI-based ultrasound imaging system.
resultsThe study included 50 patients (21 men and 29 women) with a mean age of 57.8 ± 18.1 years. Following treatment with the HMB-enriched ONS, the prevalence of sarcopenia decreased significantly (from 24% to 18%; p = 0.01) and severe malnutrition (from 14% to 2%; p = 0.01). An improvement in BIA parameters; phase angle (0.14 ± 0.02°; p = 0.02); phase angle index (0.07 ± 0.01°/m
conclusionsThe use of an HMB-enriched ONS in DRM patients, combined with AI-based ultrasound imaging for follow-up, significantly improved their nutritional status, muscle mass and muscle quality as assessed by echogenicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.